Experimental studies of nitrobenzene hydrogenation in a microstructured falling film reactor

Yeong, Kay Kin; Gavriilidis, Asterios; Zapf, Ralf; Hessel, Volker

doi:10.1016/j.ces.2004.04.022

Cited by 95 publications

(50 citation statements)

References 10 publications

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“…The interfacial area -to -volume ratio of gas-liquid twophase flow in microchannels was demonstrated to be much higher than that in conventional tubes (Haverkamp et al, 2001;Yue et al, 2006;Fu et al, 2010) and the mass transfer process was greatly enhanced. Therefore, microchannels could be used efficiently and safely in gas absorption, desorption, direct fluorination, hydrogenation and other processes (Tegrotenhuis et al, 2000;Jǎhnisch et al, 2000;Demas et al;2003;Yeong et al, 2004;Kobayashi et al, 2004). There are many reports (Jepsen, 1970;Irandoust and Andersson, 1988;Irandoust et al, 1992;Tortopidis and Bontozoglou, 1997;Bercic and Pintar, 1997;Kreutzer, 2003;Van Baten and Krishna, 2004;Vandu et al, 2005;Yue et al, 2009) on the gas-liquid two-phase mass transfer process.…”

Section: Introductionmentioning

confidence: 99%

Experimental investigation of the liquid volumetric mass transfer coefficient for upward gas-liquid two-phase flow in rectangular microchannels

Zhu

et al. 2010

Braz. J. Chem. Eng.

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-The gas-liquid two-phase mass transfer process in microchannels is complicated due to the special dynamical characteristics. In this work, a novel method was explored to measure the liquid side volumetric mass transfer coefficient k L a. Pressure transducers were utilized to measure the pressure variation of upward gas-liquid two-phase flow in three vertical rectangular microchannels and the liquid side volumetric mass transfer coefficient k L a was calculated through the Pressure-Volume-Temperature correlation of the gas phase. Carbon dioxide-water, carbon dioxide-ethanol and carbon dioxide-n-propanol were used as working fluids, respectively. The dimensions of the microchannels were 40 μm×240 μm (depth×width), 100 μm×800 μm and 100 μm×2000 μm, respectively. Results showed that the channel diameter and the capillary number influence k L a remarkably and that the maximum value of k L a occurs in the annular flow regime. A new correlation of k L a was proposed based on the Sherwood number, Schmidt number and the capillary number. The predicted values of k L a agreed well with the experimental data.

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Section: Introductionmentioning

confidence: 99%

Experimental investigation of the liquid volumetric mass transfer coefficient for upward gas-liquid two-phase flow in rectangular microchannels

Zhu

et al. 2010

Braz. J. Chem. Eng.

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“…24 10 800 to 28 000 h À1 depending on liquid flow. [31] Owing to the setup (pumps, diameter of tubing), shorter residence times were not possible in our case.…”

Section: Oxygen Mass Transfer Characteristics Of the Compared Systemsmentioning

confidence: 85%

A Falling‐Film Microreactor for Enzymatic Oxidation of Glucose

et al. 2014

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“…NB hydrogenation is best performed in a small batch tank reactor (Figure 1a) or in the falling-film microreactor (Figure 1d). Nitrobenzene hydrogenation has indeed been performed with microstructured reactor before this work but at very low scale [37]. The use of a batch tank reactor for a very exothermic reaction at large scale would be however disfavored for heat removal limitations.…”

Section: Resultsmentioning

confidence: 99%

A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry

Doan¹,

Stavárek²,

Bellefon³

2012

J Flow Chem

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A methodology that may be applied to help in the choice of a continuous reactor is proposed. In this methodology, the chemistry is first described through the use of eight simple criteria (rate, thermicity, deactivation, solubility, conversion, selectivity, viscosity, and catalyst). Then, each reactor type is also analyzed from their capability to answer each of these criteria. A final score is presented using "spider diagrams." Lower surfaces indicate the best reactor choice. The methodology is exemplified with a model substrate nitrobenzene and a target pharmaceutical intermediate, N-methyl-4-nitrobenzenemethanesulphonamide, and for three different continuous reactors, i.e., stirred tank, fixed bed, and an advanced microstructured reactor. Comparison with the traditional batch reactor is also provided.

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Experimental studies of nitrobenzene hydrogenation in a microstructured falling film reactor

Cited by 95 publications

References 10 publications

Experimental investigation of the liquid volumetric mass transfer coefficient for upward gas-liquid two-phase flow in rectangular microchannels

Experimental investigation of the liquid volumetric mass transfer coefficient for upward gas-liquid two-phase flow in rectangular microchannels

A Falling‐Film Microreactor for Enzymatic Oxidation of Glucose

A Method to Identify Best Available Technologies (BAT) for Hydrogenation Reactors in the Pharmaceutical Industry

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