Experimental Studies on Chronic Paronychia

Stone, Orville J.; Mullins, J. Fred

doi:10.1001/archderm.1964.01590270141032

Cited by 21 publications

(3 citation statements)

References 4 publications

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“…Our hypothesis also explains the differing results of experimental infection. Stone & Mullins (1964) succeeded in establishing an acute C. albicans infection after occlusion of the nail-fold with adhesive tape for 30 days. However, at that time, neither rounding out nor retraction of the nail-fold had occurred; but they did occur 7-10 days after removal of the tape.…”

Section: Discussionmentioning

confidence: 99%

Chronic Candida albicans paronychia in adult Israeli women

Ganor

Pumpianski

2006

British Journal of Dermatology

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SUMMARY The infected fingers in chronic paronychia were mostly on the dominant hand. Little fingers were less and middle fingers more affected than expected. Oral Candida albicans carriage was significantly less when the first finger to be infected was the middle finger. The duration of the disease was related to the number of infected fingers, but not to oral C. albicans carriage. The second finger to be infected was an opposite* or adjacent finger more often than expected. The following conclusions are drawn: (i) The mouth and the bowel, but not the vagina, of the patient, or her family, are sources of C. albicans in chronic paronychia. (2) Mechanical trauma that destroys the cuticle is responsible for the invasion of C. albicans into the nail‐fold. (3) This trauma in our patients is mostly due to rubbing during hand‐washing of clothes.

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Section: Discussionmentioning

confidence: 99%

Chronic Candida albicans paronychia in adult Israeli women

Ganor

Pumpianski

2006

British Journal of Dermatology

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“…Whittle and Gresham [4] experimentally demonstrated the infection of the nail fold by C. guillorondii and C. parapsilosis following prolonged occlusion of the finger. Stone and Mullin [5] reported a series of experimental studies indicate that chronic paronychia develop only in presence of C. albicans after prolonged occlusion of nail fold for 30 days. In 1990, Al-Sogair et al [6] endorsed that yeasts, especially C. albicans were an important cause of disease of nails and skin in Saudi Arabia.…”

Section: Introductionmentioning

confidence: 99%

Candida and Other Yeasts as Nail Pathogens in Chronic Paronychia and Onycholysis of Fingernails

Al-Dwibe¹,

Ghazil²,

Kalifa³

2018

JAMMR

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Paronychia and onycholysis are the common nail disorders with similar fundamental pathological findings. Fungi especially yeasts are frequently isolated. Seventy six patients with chronic paronychia and onycholysis attending the dermatology clinic in Tripoli Medical Center (TMC) were enrolled in a one year study. A detailed history and clinical examination was taken. The majority of cases were females (97.4%), with female to male ratio of 37.5:1. A history of chronic exposure to water was obtained in 88.2% of cases. Chronic paronychia was more common on the right hand; the right middle finger was the most commonly affected organ. Nail clippings and debris under nails were collected for direct microscopic examination and culture. Candida albicans was the most frequently isolated organism (37.9%), followed by Candida tropicalis (30%); C.parapsilosis (20%) and other yeasts were isolated less frequently. This study revealed that C. albicans and other yeasts were important causes of chronic paronychia and onycholysis in the country.

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“…In addition. Stone and Mullins (1964) stated that the acute flare, which occurs from time to time in the persistent low-grade inflammation, was simply a form of acute, intertriginous dermatitis under the proximal nail-fold.…”

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confidence: 99%

Etretinate and the nails (study of 130 cases) possible mechanisms of some side-effects

Baran

1986

Clin Exp Dermatol

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Summary With the exception of acropustulosis, nail disease responds poorly to etretinate. When used to treat other dermatological conditions etretinate is frequently toxic to the normal nail and may affect any or all of its epidermal components. The desquamative dermatitis, induced by etretinate, may account for many of the drug's side‐effects on the nail. These include chronic paronychia, onycholysis, onychomadesis, nail shedding, onychoschizia, fragility and the formation of excess granulation tissue. Some of these changes resemble those found in psoriatic paronychia and similarities are drawn between psoriasis and the retinoid dermatitis which presents with identical features in the discharge from beneath the proximal nail‐fold. The desquamative reaction in patients taking etretinate always affects the lips and, in addition, may be widespread or mainly localized to the nail apparatus.

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Experimental Studies on Chronic Paronychia

Cited by 21 publications

References 4 publications

Chronic Candida albicans paronychia in adult Israeli women

Chronic Candida albicans paronychia in adult Israeli women

Candida and Other Yeasts as Nail Pathogens in Chronic Paronychia and Onycholysis of Fingernails

Etretinate and the nails (study of 130 cases) possible mechanisms of some side-effects

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