Experimental studies on enteropathogenicity of Vibrio cholerae serotypes other than 1

Prem, Shankar; Agarwal, Rajiv; Sanyal, Sudip

doi:10.1016/s0174-3031(82)80028-0

Cited by 11 publications

(2 citation statements)

References 19 publications

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“…The observation that all the isolates of A. jandaei and a majority of A. trota failed to cause fluid accumulation in the initial set of experiments but did so after one to five sequential passages through RIL indicates that all these strains are potentially enterotoxigenic. Similar observations on switching over to toxin production by an apparently non‐toxic strain on consecutive passages through the gut of a susceptible host were made in our earlier studies with other Aeromonas species [3, 10–12]and organisms such as V. cholerae non‐O1 [19], Plesiomonas shigelloides [20], V. fluvialis [21], V. mimicus [17, 22], Klebsiella pneumoniae [23]and CT gene‐negative V. cholerae O1 [18]. Such a change may result from the existence of a repression‐derepression phenomenon controlling the expression of a toxin gene depending on a particular micro‐environment [24].…”

Section: Discussionsupporting

confidence: 84%

Enteropathogenicity ofAeromonas jandaeiandA. trota

Singh

Sanyal

1997

FEMS Immunol Med Microbiol

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An experimental study of five isolates of Aeromonas jandaei and 12 of A. trota was carried out to examine if they produced an enterotoxic substance, and if so, to characterise that factor and to see if it caused any mucosal damage. Only two of the A. trota strains caused fluid accumulation in the initial rabbit ileal loop (RIL) tests. The remaining strains did so only after one to five sequential passages through RILs and once they caused a secretory response they showed a gradual enhancement of fluid outpouring after each subsequent passage. Inocula of approximately 1 x 10(5) viable cells and 0.25 ml of culture filtrate caused fluid accumulations comparable to those of toxigenic V. cholerae 569B. The enterotoxic factors of both organisms were inactivated when held at 56 degrees C for 20 min or 65 degrees C for 10 min and showed biological activity over a wide range of pH. The only histopathological change observed in the ileal loop was depletion of mucus from the goblet cells. These data thus indicate that strains of A. jandaei and A. trota may produce a heat-labile and pH-stable diarrhoeagenic substance that causes little or no damage to the intestinal mucosa, like that of other known heat-labile enterotoxins.

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Section: Discussionsupporting

confidence: 84%

Enteropathogenicity ofAeromonas jandaeiandA. trota

Singh

Sanyal

1997

FEMS Immunol Med Microbiol

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“…Similar observations were made with enterotoxic A. hydrophila, V. cholerae serotypes other than O1 19 . Strain to strain variations in the amount of fluid accumulation was probably due to differences in the quantitative release of the toxin from cells into the medium 22 and to biological variations in rabbits 23 .…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Comparison of toxicities between Vibrio fluvialis and Vibrio furnissii strains isolated from environmental samples

Jainab

Hasan

Manchur

et al. 2022

Bangla. J. Microbiol.

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Gastrointestinal episodes associated with Vibrio species have been rising worldwide in the last few years. In this study, toxicities of two very well characterized V. fluvialis and V. furnissii strains, isolated from environmental samples, were used to investigate the comparative pathogenicity of these strains. The results showed that there is a positive relationship between toxin production as well as a high interspecies correlation. In the analysis of toxicity, both species showed positive results with close similarity in cell death on BHK-21 cell line and destruction of RBC, which were indicative of cytotoxic and hemolytic activity, respectively. Besides, molecular analysis showed the absence of ctx, tdh, trh, stx1 and stx2 genes. On the other hand, reduced fluid accumulation ratio in rabbit ileal loop assay and paralysis of hind legs of Swiss Albino mice were observed for V. furnissi strain, which indicates the differences in pathogenicity between the two species. Bangladesh J Microbiol, Volume 38, Number 2, December 2021, pp 73-77

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Nag vibrio toxin

Sanyal

1983

Pharmacology & Therapeutics

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Experimental studies on enteropathogenicity of Vibrio cholerae serotypes other than 1

Cited by 11 publications

References 19 publications

Enteropathogenicity ofAeromonas jandaeiandA. trota

Enteropathogenicity ofAeromonas jandaeiandA. trota

Comparison of toxicities between Vibrio fluvialis and Vibrio furnissii strains isolated from environmental samples

Nag vibrio toxin

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