Experimental studies on preparation of the porous and small-diameter poly(ε-caprolactone) external vascular scaffold and its degradability and biocompatibility

Abstract

The porous PCL-1-50 external vascular scaffold, with the 50% concentration of NaCl, had the maximum porosity on the basis of enough mechanical strength which meets the demand of clinical vascular transplantation. Moreover, it had good biocompatibility with rADSCs and the degradation mechanism of the scaffold was surface degradation.

Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

“…Compared with the PGA, polycaprolactone (PCL) has a slower degradation rate and provides adequate mechanical properties effectively [ 20 ]. The porous scaffolds made of PCL have sufficient mechanical strength and porosity to satisfy the demand for clinical vascular transplantation [ 21 ]. However, poor regeneration of vascular walls, irregular cell infiltration and partial calcification are still obstacles to limiting PCL applications in the long run [ 22 ].…”