Experimental studies on reproductive toxicologic effects of lamotrigine in mice

Padmanabhan, R.; Abdulrazzaq, Yousef M.; Bastaki, Salim M. A.; Shafiullah, Mohamed; Chandranath, S.I.

doi:10.1002/bdrb.10042

Cited by 26 publications

(28 citation statements)

References 59 publications

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“…The LMT exposure resulted in a significant increase of resorptions and craniofacial malformations (exencephaly, cleft palate, arched palate and midfacial hypoplasia), urogenital abnormalities and varying degrees of caudal regression and skeletal defects were also noted. These observed effects were most likely secondary to the severe maternal toxicity observed in the treated dams [85,86]. One study has reported a folate-mediated rescue of LMT-induced cleft palate [87].…”

Section: Mechanisms Of Aed Teratogenicitymentioning

confidence: 99%

Teratogenic effects of antiepileptic drugs

Hill

Wlodarczyk

Palacios

et al. 2010

Expert Review of Neurotherapeutics

127

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Many antiepileptic drugs (AEDs) have therapeutic applications that extend beyond epilepsy to include neuropathic pain, migraine headaches and psychiatric disorders. The risk of some AEDs has been clearly established, but for newer drugs, small sample sizes and polytherapy exposures preclude a conclusive determination of their teratogenic potential. Most women with epilepsy will require AED therapy throughout their entire pregnancy to control seizures; the vast majority of pregnancies in women with epilepsy have positive outcomes. A conservative estimate suggests that AED monotherapy doubles, and polytherapy triples, the risk for major congenital malformations. Furthermore, while evidence is still accruing, recent investigations suggest that exposure to select AEDs results in altered cognitive function later in development. There is no evidence to suggest that additional folic acid supplementation ameliorates the increased risk of congenital malformations conferred by in utero AED exposure.

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Section: Mechanisms Of Aed Teratogenicitymentioning

confidence: 99%

Teratogenic effects of antiepileptic drugs

Hill

Wlodarczyk

Palacios

et al. 2010

Expert Review of Neurotherapeutics

127

View full text Add to dashboard Cite

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“…Resorption and reduction of fetal weight were seen both being dose dependent. Skeletal malformation found in these studies were assigned to the maternal toxicity, however neural tube defects (anencephaly), malformation related to the cranial crest cells, and caudal dysgenesis were probably induced by lamotrigine (Padmanabhan et al, 2003). Prenatal exposure to LTG induced altered brain structure in a dose-dependent manner at maternal plasma concentrations within the clinically occurring range (Manent et al, 2008).…”

Section: Third Generation Of Antiepileptic Drugs 431 Lamotrigine (Ltg)mentioning

confidence: 89%

Epilepsy and Anticonvulsant Therapy During Pregnancy

Maňáková¹,

Hubickova²

2011

Novel Treatment of Epilepsy

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“…The LMT exposure resulted in a significant increase of resorptions and craniofacial malformations (exencephaly, cleft palate, arched palate and midfacial hypoplasia), urogenital abnormalities and varying degrees of caudal regression and skeletal defects were also noted. It should be noted that the observed effects were most likely secondary to the severe maternal toxicity observed in the treated dams [Bastaki et al, 2001;Padmanabhan et al, 2003]. One study has reported a folate-mediated rescue of LMTinduced cleft palate .…”

Section: Lamotrigine (Lamictal)mentioning

confidence: 99%

Antiepileptic Drugs and Pregnancy Outcomes

Wlodarczyk

Palacios

George³

et al. 2012

Obstetrical &Amp; Gynecological Survey

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The treatment of epilepsy in women of reproductive age remains a clinical challenge. While most women with epilepsy require anticonvulsant drugs for adequate control of their seizures, the teratogenicity associated with some antiepileptic drugs is a risk that needs to be carefully addressed. Antiepileptic medications are also used to treat an ever broadening range of medical conditions such as bipolar disorder, migraine prophylaxis, cancer and neuropathic pain. Despite the fact that the majority of pregnancies of women with epilepsy who are receiving pharmacological treatment are normal, studies have demonstrated that the risk of having a pregnancy complicated by a major congenital malformation is doubled when comparing the risk of untreated pregnancies. Furthermore, when antiepileptic drugs (AEDs) are used in polytherapy regimens, the risk is tripled, especially when valproic acid (VPA) is included. However, it should be noted that the risks are specific for each anticonvulsant drug. Some investigations have suggested that the risk of teratogenicity is increased in a dose-dependent manner. More recent studies have reported that in utero exposure to AEDs can have detrimental effects on the cognitive functions and language skills in later stages of life. In fact, the FDA just issued a safety announcement on the impact of VPA on cognition (Safety Announcement 6-30-2011). The purpose of this document is to review the most commonly used compounds in the treatment of women with epilepsy, and to provide information on the latest experimental and human epidemiological studies of the effects of antiepileptic drugs in the exposed embryos.

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Experimental studies on reproductive toxicologic effects of lamotrigine in mice

Cited by 26 publications

References 59 publications

Teratogenic effects of antiepileptic drugs

Teratogenic effects of antiepileptic drugs

Epilepsy and Anticonvulsant Therapy During Pregnancy

Antiepileptic Drugs and Pregnancy Outcomes

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