Pedestrian route choice, the process by which individuals decide on their walking path between two locations, is a fundamental problem across disciplines. Because this behaviour is investigated from different conceptual and methodological angles, and because it strongly depends on the environmental context, it is challenging to establish a systematic framework for research. Here, by reviewing previous work, we identify four principles for pedestrian route choice that are relevant across disciplines. First, ‘information perception’ deals with how pedestrians can perceive information selectively and purposely, given the limited available information. Second, ‘information integration’ considers how pedestrians subjectively integrate environmental spatial information into mental representations. Third, ‘responding to information’ is concerned with how pedestrians tend to be attracted and repelled by specific attributes individually and how this can lead to positive or negative feedback loops across many individuals. Fourth ‘decision-making mechanisms' describe how pedestrians trade off the evidence provided by different attributes. How pedestrians perceive, integrate, respond to, and act upon information is not fixed but varies with the context. We give examples for each principle and explain how these principles shape pedestrian choice behaviours. We hope this contribution provides a systematic overview of the field and helps to spark inspiration among specialists.