Experimental Study for the Effect of Methyl Rednisolone on the Sexual Hormones Levels

Abstract

Methylprednisolone is one of the steroid drugs (Glucocorticoid) , which is used in many medical conditions including allergy , ulcerative Colitis , Lupus , psoriasis , respiratory disorders and immune inhibitory. Fifty sex adult male rats weighing (225-250) gm where used, and randomly divided into four equal groups, which treated with daily by three different concentration from Methylprednisolone drug : (10,30,40) mg/kg/day. The blood samples is taken in the first and second week of dosage from all groups. The results of this study showed that the drug has obvious effect on the sexual hormones ( Testosterone hormone , LH hormone, FSH hormone and Prolactin hormone ) in sera of rats under investigation , In which the maximum change in the levels of hormones were showed in sera of groups with high dosage from drug (40 mg/kg) and the minimum change at the low dosage (20 mg/kg) . The results are indicated there is significant decrease in testosterone levels, LH and FSH the decrease is continued until the second week . As for the Prolactin hormone , the results indicated there is a significant increased and increase is continued until the second week .