Experimental study for the production cross sections of positron emitters induced from 12C and 16O nuclei by low-energy proton beams

Akagi, Takashi; Yagi, Masashi; Yamashita, Tomohiro; Murakami, Masao; Yamakawa, Yoshiyuki; Kitamura, Kazuhiro; Ogura, K.; Kondo, Kimito; Kawanishi, Shunichi

doi:10.1016/j.radmeas.2013.07.005

Cited by 24 publications

(38 citation statements)

References 29 publications

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“…As the normalization of the Cherenkov radiation intensity as measured by the EM-CCD was arbitrary, the resultant cross sections were only given in relative units and difficult to quantify. As the first attempt in this study, we used the archival data of 16 O( p,x ) 15 O 23 , 26 that was the most densely sampled with the least uncertainty, and the results agreed with others in literature. Note that the acquired cross section and archival data peaked at almost same energy, 35 MeV.…”

Section: Resultssupporting

confidence: 75%

“…Therefore, cross sectional data of the nuclear reactions that produce positron emitters are important, particularly for the components of the human body, for e.g., oxygen, carbon, and calcium. However, the current database of such nuclear reactions is insufficient below 250 MeV, which are important for proton therapy 6 – 8 , 10 , 11 , 14 , 23 , 24 . The lower energy region (under ∼70 MeV) is especially important because decelerated protons damage tumors most effectively 14 , 23 , 24 .…”

Section: Introductionmentioning

confidence: 99%

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Measurement of nuclear reaction cross sections by using Cherenkov radiation toward high-precision proton therapy

Masuda

Kataoka

Arimoto

et al. 2018

Sci Rep

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Monitoring the in vivo dose distribution in proton therapy is desirable for the accurate irradiation of a tumor. Although positron emission tomography (PET) is widely used for confirmation, the obtained distribution of positron emitters produced by the protons does not trace the dose distribution due to the different physical processes. To estimate the accurate dose from the PET image, the cross sections of nuclear reactions that produce positron emitters are important yet far from being sufficient. In this study, we measured the cross sections of 16O(p,x)15O, 16O(p,x)13N, and 16O(p,x)11C with a wide-energy range (approximately 5–70 MeV) by observing the temporal evolution of the Cherenkov radiation emitted from positrons generated via β+ decay along the proton path. Furthermore, we implemented the new cross sectional data into a conventional Monte Carlo (MC) simulation, so that a direct comparison was possible with the PET measurement. We confirmed that our MC results showed good agreement with the experimental data, both in terms of the spatial distributions and temporal evolutions. Although this is the first attempt at using the Cherenkov radiation in the measurements of nuclear cross sections, the obtained results suggest the method is convenient and widely applicable for high precision proton therapy.

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Section: Resultssupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Measurement of nuclear reaction cross sections by using Cherenkov radiation toward high-precision proton therapy

Masuda

Kataoka

Arimoto

et al. 2018

Sci Rep

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“…However, it varies in the range of 80-100 mb at about 30-40 MeV, showing wide variation among experiments, in 2 patterns for the energy range of 50-200 MeV. The cross section of the 12 C(p, pn) 11 C reaction derived by measuring annihilation γ-ray activity after target irradiation using PET for medical use have recently been reported, in which the experimental value was about 70-80 mb, being slightly lower than those in other reports, although the data were collected only at only 4 proton beam energy of 32.5, 47.5, 59.4, and 69.6 MeV [18]. For the 12 C(p, p2n) 10 C reaction, the cross section have been reported at only 2 proton energies of 143 and 155 MeV [11,23].…”

Section: Introductionmentioning

confidence: 88%

“…The influence of flux variation due to the positional resolution of the PET is also take into account (see Discussion for detail). Those data can be classified in the group of a lower cross section such as Measday et al, Gauvin,Akagi et al.,and Panofsky et al[8,9,13,18], and higher cross section such as Whitehead et al, Hintz et al,and Aamodt et al[4,10,12]. Also, the errors in both energy and cross section of some data (Gauvin, Whitehead et al, Hintz et al and Aamodt et al) were not given in the EXFOR database.…”

Section: Derivation Of Cross Sectionmentioning

confidence: 99%

“…The human body is mainly composed of hydrogen, carbon, oxygen, and calcium nuclei, and the production cross section of positron emitters ( 10 C, 11 C, 13 N, 14 O, 15 O, 38 K, 38 Ca, and 39 Ca) generated between the 3 elements excluding hydrogen and incident proton nucleus are important to estimate the range and exposure dose distribution in the patient's body. The cross section of 11 C, 15 O and 13 N were measured at several proton energy [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], however, those quantity and accuracy is insufficient yet. The cross section of 10 C, 14 O, 38 K and 39 Ca were measured only a few point [11,23,24].…”

Section: Introductionmentioning

confidence: 99%

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Measurement of proton-induced target fragmentation cross sections in carbon

et al. 2016

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In proton therapy, positron emitter nuclei are generated via the target nuclear fragmentation reactions between irradiated proton and nuclei constituting a human body. The proton-irradiated volume can be confirmed with measurement of annihilation γ-rays from the generated positron emitter nuclei. To achieve the high accuracy of proton therapy, in vivo dosimetry i.e., evaluation of the irradiated dose during the treatment is important. To convert the measured activity distribution to irradiated dose, cross section data for positron emitter production is necessary, which is currently insufficient in the treatment area. The purpose of this study is to collect cross section data of 12 C(p, pn) 11 C and 12 C(p, p2n) 10 C reactions between the incident proton and carbon nuclei, which are important target nuclear fragmentation reactions, to estimate the range and exposure dose distribution in the patient's body. Using Planar-type PET capable of measuring annihilation γ-rays at high positional resolution and thick polyethylene target, we measured cross section data in continuous wide energy range. The cross section of 12 C(p, pn) 11 C is in good agreement with existing experimental data. The cross section of 12 C(p, p2n) 10 C is reported for the first data in the low energy range of 67.6-10.5 MeV near the Bragg-peak of proton beam.

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New developments in the experimental data for charged particle production of medical radioisotopes

Ditrói

Tárkányi

Takács

et al. 2015

J Radioanal Nucl Chem

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The goal of the present work is to give a review of developments achieved experimentally in the field of nuclear data for medically important radioisotopes in the last three years. The availability and precision of production related nuclear data is continuously improved mainly experimentally. This review emphasizes a couple of larger fields: the Mo/Tc generator problem and the generator isotopes in general, heavy alpha-emitters and the rare-earth elements. Other results in the field of medical radioisotope production are also listed.

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Experimental study for the production cross sections of positron emitters induced from 12C and 16O nuclei by low-energy proton beams

Cited by 24 publications

References 29 publications

Measurement of nuclear reaction cross sections by using Cherenkov radiation toward high-precision proton therapy

Measurement of nuclear reaction cross sections by using Cherenkov radiation toward high-precision proton therapy

Measurement of proton-induced target fragmentation cross sections in carbon

New developments in the experimental data for charged particle production of medical radioisotopes

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