Experimental study in the dog of the non-active role of the tooth in the eruptive process

Marks, Sandy C.; Cahill, Donald R.

doi:10.1016/0003-9969(84)90105-5

Cited by 180 publications

(108 citation statements)

References 15 publications

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“…The present findings lead to the possibility that the initiation of root resorption of deciduous teeth is a programmed physiological event like tooth eruption and that site-and time-specific recruitment and differentiation of odontoclasts at the onset of root resorption of the deciduous tooth might be regulated by the dental follicle of the permanent tooth. This assumption is supported by the experimental evidence that resorption of overlying bone to form an eruption pathway and that of deciduous roots occurred even when bodily movement of the tooth was prevented by trans-mandibular wires (Cahill, 1969), and by the finding that removal of the tooth leaving the dental follicle in situ had no effect on the coordinated sequence of resorption of alveolar bone and deciduous roots (Marks and Cahill, 1984).…”

Section: Discussionmentioning

confidence: 91%

Cellular events at the onset of physiological root resorption in rabbit deciduous teeth

Sahara

2001

Anat. Rec.

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For elucidation of how physiological root resorption of deciduous teeth is initiated, the cellular events that occur surrounding the root of rabbit deciduous teeth before and at the onset of physiological root resorption were observed by means of light and electron microscopy. In addition, the cytodifferentiation of odontoclasts during the initial phase of this root resorption was evaluated by histochemical staining of tartrate-resistant acid phosphatase (TRAP) activity as a marker odontoclasts and their precursors. The present investigation was focused on the physiological root resorption of the deciduous lower second molar of rabbits from Day 0 -5 postnatally. At birth, the deciduous molar had not erupted yet, and no TRAP-positive cell could be found surrounding the tissue adjacent to the root of the deciduous tooth. TRAP-positive mononuclear cells were initially detected in the coronal portion of the dental follicle of the permanent tooth at Day 1 postnatally. Ultrastructurally, these mononuclear cells had moderate numbers of mitochondria and short-strand rough endoplasmic reticulum, as well as scattered free ribosomes throughout their cytoplasm. TRAP-positive mononuclear cells then appeared in the cementoblast layer immediately adjacent to the surface of the deciduous roots. These mononuclear cells projected cytoplasmic extensions between the cementoblasts and made contact with the cementum. At that time, cell-cell contact was frequently observed between these mononuclear cells and cementoblasts. During 3-5 days postnatally, the number of TRAP-positive multinucleate odontoclasts on the root surface gradually increased. They had well-developed ruffled borders and made typical resorption lacunae on the root surface of the deciduous tooth. During this early postnatal period, neither inflammatory cells nor necrotic tissue could be observed surrounding the deciduous root. This study demonstrates that the dental follicle of the permanent tooth as well as the connective tissue adjacent to the deciduous root might play important role in siteand time-specific recruitment, development, and activation of odontoclasts before and at the onset of physiological root resorption. Anat Rec 264: [387][388][389][390][391][392][393][394][395][396] 2001.

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Section: Discussionmentioning

confidence: 91%

Cellular events at the onset of physiological root resorption in rabbit deciduous teeth

Sahara

2001

Anat. Rec.

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“…One of these questions concerns the effect of the bone graft on the eruption of the permanent canine, In our institute, chin bone, intramembraneoiis in origin, is the grafting material of choice (Freihofer et al, 1993). Membraneous bone has several ad van» 1982; Hoppenreijs et ah, 1993) and it has been shown that it is tages over enchondral bone: it is usually removed less subject to postoperative remodelling and resorp (Marks et al, 1983; to be known of the healing process in osseous defects Wise et al, 1985) and that eruption depends on the resembling the volume of alveolar clefts, dental follicle proper, a thin collagenous investment of the crown of each developing tooth (Marks and Cahill, 1984;Cahill and Marks, 1980;. This cell-mediated process results in a local tuning o f the erupting tooth and the overlying alveolar bone.…”

Section: Discussionmentioning

confidence: 99%

Tooth eruption through autogenous and xenogenous bone transplants: a histological and radiographic evaluation in beagle dogs

Merkx

Maltha

Hoff

et al. 1997

Journal of Cranio-Maxillofacial Surgery

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S U M M A R Y . The effect of implanting autogenous and xenogenous (Bio-Oss) bone transplants into metabolically active sites within beagle dog mandibles during permanent premolar tooth eruption was examined. Ten 14-weekold beagles were used. Before commencing the radiographic experiments, metal bone markers were placed in the caudal margin of the mandible at the age of 10 weeks. The deciduous first and third molar teeth were extracted and their sockets over the permanent second and fourth premolars were implanted with autogenous particulate enchondral iliac crest bone, autogenous particulate membraneous mandibular body bone, xenogenous bovine anorganic bone mineral spongiosa granules (1 -2 mm3) (Bio-Oss, Geistlich Pharma, Switzerland) or left empty. The third premolar served as a control site. Standardized oblique lateral radiographs were taken once a week. A number of coordinates of defined points and structures were determined by means of a coordinate digitizing system. Animals were killed 4, 10 and 16 weeks after bone transplantation for histological examination of the transplan tation sites. All premolars showed no delay in eruption or disruption of crown and root development. On histology, the Bio-Oss particles were not resorbed or integrated in the alveolar bone but were pushed forward into the gingiva. We have demonstrated that there is no difference in the eruption curve of the permanent premolars in the four groups (ANOVA ^> 0 .5 ) and that bone transplantation has no inhibitory effect on eruption (ÀNO VÀ P > 0 .3 ) and crown development of the underlying permanent premolar but that Bio-Oss does not have the same resorbable or integrating capability as autogenous bone grafts.

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“…In contrast, leaving the DF intact, but removing the tooth and inserting an artificial replica of the tooth such as dental amalgam, resulted in eruption of the artificial tooth (Marks and Cahill, 1984). This experiment eliminated many previous theories of eruption, because possible propulsive tissues such as the dental pulp and roots were absent.…”

Section: (B) Role Of Dental Folliclementioning

confidence: 95%

Cellular, Molecular, and Genetic Determinants of Tooth Eruption

Wise

Frazier‐Bowers

D’Souza

2002

Critical Reviews in Oral Biology & Medicine

334

239

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Tooth eruption is a complex and tightly regulated process that involves cells of the tooth organ and the surrounding alveolus. Mononuclear cells (osteoclast precursors) must be recruited into the dental follicle prior to the onset of eruption. These cells, in turn, fuse to form osteoclasts that resorb alveolar bone, forming an eruption pathway for the tooth to exit its bony crypt. Some of the molecules possibly involved in the signaling cascades of eruption have been proposed in studies from null mice, osteopetrotic rodents, injections of putative eruption molecules, and cultured dental follicle cells. In particular, recruitment of the mononuclear cells to the follicle may require colony-stimulating factor-one (CSF-1) and/or monocyte chemotactic protein-1 (MCP-1). Osteoclastogenesis is needed for the bone resorption and may involve inhibition of osteoprotegerin transcription and synthesis in the follicle, as well as enhancement of receptor activator of NF B ligand (RANKL), in the adjacent alveolar bone and/or in the follicle. Paracrine signaling by parathyroid-hormone-related protein and interleukin -1␣, produced in the stellate reticulum adjacent to the follicle, may also play a role in regulating eruption. Osteoblasts might also influence the process of eruption, the most important physiologic role likely being at the eruptive site, in the formation of osteoclasts through signaling via the RANKL/OPG pathway. Evidence thus far supports a role for an osteoblast-specific transcription factor, Cbfa1 (Runx2), in molecular events that regulate tooth eruption. Cbfa1 is also expressed at high levels by the dental follicle cells. This review concludes with a discussion of the several human conditions that result in a failure of or delay in tooth eruption.

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Experimental study in the dog of the non-active role of the tooth in the eruptive process

Cited by 180 publications

References 15 publications

Cellular events at the onset of physiological root resorption in rabbit deciduous teeth

Cellular events at the onset of physiological root resorption in rabbit deciduous teeth

Tooth eruption through autogenous and xenogenous bone transplants: a histological and radiographic evaluation in beagle dogs

Cellular, Molecular, and Genetic Determinants of Tooth Eruption

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