Experimental Study of Autologous Cartilage, Acellular Cadaveric Dermis, Lyophilized Bovine Pericardium, and Irradiated Bovine Tendon

Abstract

The purpose of this study was to compare the volumetric and histologic changes of the acellular cadaveric dermis, lyophilized bovine pericardium, irradiated bovine tendon, and autologous cartilage transplanted subcutaneously in the rats. Four different kinds of implants were placed in subcutaneous pockets of the dorsum of 40 Wister rats. The implants with the subcutaneous pockets were retrieved in the first, fourth, eighth, and 12th weeks after implantation. The size and histologic change of each implant were observed. The xiphoid cartilage showed the peak survival (71.0%, P = 0.247) on the 12th week, but part of the cartilage was absorbed irregularly and its shape changed unpredictably. The lyophilized bovine pericardium had a high survival rate as well (64.4%, P = 0.016). However, the size decreased significantly in the first through 12th weeks. A survival of acellular cadaveric dermis was lower (38.8%, P = 0.036) than the cartilage and pericardium, but it sustained the structure for 12 weeks and changed peripherally into the neocollagen. Irradiated bovine tendon disclosed the lowest survival rate (31.4%, P = 0.008). The structure was gradually distorted and replaced entirely by neocollagen in the 12th week after implantation. Autologous cartilage is the best choice for soft tissue and nasal tip augmentation. Although other implants than the cartilage showed significant diminution of its volume in 12 weeks, lyophilized bovine pericardium could be the next substitute to the cartilage in soft tissue augmentation.

Do Cells Contribute to Tendon and Ligament Biomechanics?

“…For this purpose, the scaffolds are chemically cross-linked [3], [7], [8] or seeded with growth factors [9]. A diversity of acellular tissues is used for this purpose, such as dermis [5], [10]–[12], pericardium [7], [13], ligaments and tendons [6], [14] or small intestine submucosa [3], [5], [15]. These tissues mostly originate from human, bovine, caprine, equine or porcine donors [15].…”

Use of Fetal Bovine Acellular Dermal Xenograft With Tissue Expansion for Staged Breast Reconstruction

“…Craft and May chose bovine collagen after Hwang et al had demonstrated the superiority of bovine collagen in nasal tip augmentation in terms of angiogenesis, invasion of host fibroblasts, and deposition of collagen fibers when compared with human cadaveric dermis. 8 In our review of the literature, the use of FBADM as a sling for the lower third of the expander pocket has not yet been reported. In addition to type I collagen, the primary collagen of human skin, FBADM is rich in type III collagen.…”

A Systematic Review of Comparison of Autologous, Allogeneic, and Synthetic Augmentation Grafts in Nipple Reconstruction

“…Acellular dermal matrix has been reported to decrease inflammatory response, infection rates, and implant rejection. 38 Unfortunately, the use of acellular dermal matrix poses a greater financial burden on patients. Banking any acellular dermal matrix excess at the time of breast reconstruction for a subsequent nipple reconstruction can alleviate such costs.…”