Characterized by long spans, low aspect ratios, and intricate construction sequences, super-large cross-section tunnels present substantial construction risks. Therefore, the selection of the optimal excavation method and construction sequence is crucial for ensuring the safety of tunnel construction and minimizing project costs. This paper takes a super large transverse-section highway tunnel as a case study, employing field monitoring data combined with ABAQUS software to analyze the stress and deformation of surrounding rock and support structures under different excavation methods. The findings reveal that the deformation of surrounding rock and support structures excavated by the Double-Side Drift Method is smaller than those caused by the three-benching seven-step method and the CRD excavation method. Nevertheless, the significant stresses of surrounding rock and support structures are released by the Double-Side Drift Method, leading to potential stress concentrations. Thus, it is necessary to ensure the rapid completion of early support and quick sealing of the tunnel. Furthermore, the sixth process achieves smaller deformation (including arch displacement and surface settlement) of the tunnel, a shorter construction period, and lower economic costs when compared to other construction processes. Consequently, it can obviously be concluded that both the Double-Side Drift Method and the sixth construction process stand out as the most appropriate choices for excavating super large cross-section tunnels. The insights obtained from this study provide theoretical guidance for the design and construction of similar tunnel projects.