Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds

Xu, Jiasheng; Min, Dinghong; Guo, Guang-hua; Liao, Xincheng; Fu, Zhonghua

doi:10.3892/etm.2018.6131

Cited by 23 publications

(36 citation statements)

References 40 publications

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“…FGF. We found four RCTs that evaluated the healing potential of FGF on diabetic ulcers [21][22][23][24] (Tables 5 and 6). Liquid FGF was used, for example, in the form of a spray in different concentrations of 40 U/cm 2 , 100 U/cm 2 , 500 ng/wound, 1 μg/wound, 50 μg/wound, and 500 μg/wound on a daily basis.…”

Section: Morementioning

confidence: 99%

The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials

Mahdipour

Sahebkar

2020

Journal of Diabetes Research

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Background. Recombinant proteins and growth factors are emerging therapies for diabetic foot ulcers. Despite several clinical reports, there has been no comprehensive and systematic assessment of the totality of clinical evidence on the efficacy and safety of recombinant proteins and growth factors in diabetic foot ulcers. We tried to address this gap through an updated systematic review of randomized controlled trials (RCTs). Methods. PubMed, the Cochrane Library, Scopus, Embase, and Google Scholar databases were searched, and RCTs on the efficacy of recombinant proteins and growth factors in the treatment of cutaneous wounds in diabetic patients were selected. The literature search and assessment were performed by two independent reviewers. Methodological quality of studies was appraised using the Jadad scale. Results. We identified 26 RCTs involving diabetic patients with ulcer that evaluated the effectiveness of platelet-derived growth factor, epidermal growth factor, fibroblast growth factor, granulocyte colony-stimulating factor, vascular endothelial growth factor, erythropoietin, transforming growth factor, talactoferrin, and rusalatide acetate. The main primary outcome was complete healing though different indices were employed to define this such as wound closure, granulation tissue formation, or complete reepithelialization. Few studies had a follow-up period to report any recurrence and amputation rate. No adverse effect was reported due to the intervention. Conclusion. Overall, there is a greater agreement on the effectiveness of EGF to enhance the healing of diabetic ulcers. Nevertheless, extant evidence is lacking for other agents since few trials have been conducted for most of the growth factors and available studies are heterogeneous in their methodologies.

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Section: Morementioning

confidence: 99%

The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials

Mahdipour

Sahebkar

2020

Journal of Diabetes Research

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“…(Jung, Yoo and Han, 2016) (Jung, Yoo, & Han, 2016) Medical record 1) Intervention group: hydrophilic polyurethane dressing 2) Saline dressing Total wound healing occurred in 87 patients (polyurethane dressing group) and in 28 patients in the control group within 12 weeks. (Xu et al, 2018) (Xu, Min, Guo, Liao, & Fu, 2018) Experimental: random sampling 1) EFG (Epidermal Grow Factor) Group 2) aFGF (acidic fibroblast growth factor) 3) Combination of EFG and Afgf 4) Normal saline New tissue granulation at grades 2 and 3 needed less treatment time than in the combination group.…”

Section: Improved Healing Of Diabetic Foot Ulcersmentioning

confidence: 99%

The Management of Diabetic Foot Ulcers Using the Wound Treatment Techniques of Modern Dressing: A Systematic Review

Alfaqih

Sinawang

Faizah

et al. 2020

J. Ners

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Background: One of the complications caused by diabetes mellitus is the problem of diabetic foot ulcers (DFU). The management of the DFU problem can be carried out through the wound care focused on the foot using modern dressings. This research was to determine the effectiveness of modern dressings on the healing process of diabetic foot ulcers.Methods: The methods used in arranging this systematic review were (1) the identification of interventions in the literature, (2) the identification of relevant literature based on the topic and title, (3) obtaining the literature in full-text form and (4) the analysis of the results from the various interventions in the literature.Result: The literature search was carried out in several databases such as Scopus, Google Scholar and Pubmed. The samples in this article were research about the effect of modern dressings in the treatment of diabetic foot ulcers. A total of 22 evidence bases found 10 studies using the pre-experimental method, 3 RCTs, 2 quasi-experiments, 2 articles / systematic reviews, 2 perspective studies, 1 medical report, 1 case study and 1 vitro and vivo study.Conclusion: Based on the review, it explains that the research on modern dressings using nanocrystalline silver ion and curcumin can improves wound recovery by increasing the transformation rate of the ß1 growth factor, which is a protein involved in cell growth and proliferation.

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“…Among them, acidic fibroblast growth factor (FGF1) is one of the earlier founded members of the fibroblast growth factor family. Studies have shown that FGF1 has a wide range of physiological functions, such as antioxidant damage (Pena et al, 2017), induction of endothelial and smooth muscle cell proliferation and angiogenesis (Zhao et al, 2016), promotion of tissue wound repair (Xu et al, 2018), neurotrophic regeneration (Tsai et al, 2015), etc. Therefore, FGF1 has a great potential in the prevention and treatment of DCM.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Preventive Effect Against Diabetic Cardiomyopathy of FGF1-Loaded Nanoliposomes Combined With Microbubble Cavitation by Ultrasound

Zheng

Shen

et al. 2020

Front. Pharmacol.

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Acidic fibroblast growth factor (FGF1) has great potential in preventing diabetic cardiomyopathy. This study aimed to evaluate the preventive effect of FGF1-loaded nanoliposomes (FGF1-nlip) combined with ultrasound-targeted microbubble destruction (UTMD) on diabetic cardiomyopathy (DCM) using ultrasound examination. Nanoliposomes encapsulating FGF1 were prepared by reverse phase evaporation. DM model rats were established by intraperitoneal injection of streptozotocin (STZ), and different forms of FGF1 (FGF1 solution, FGF1-nlip, and FGF1-nlip+UTMD) were used for a 12-week intervention. According to the transthoracic echocardiography and velocity vector imaging (VVI) indexes, the LVEF, LVFS, and VVI indexes (Vs, Sr, SRr) in the FGF1-nlip+UTMD group were significantly higher than those in the DM model group and other FGF1 intervention groups. From the realtime myocardial contrast echocardiography (RT-MCE) indexes, the FGF1-nlip+UTMD group A and A×b showed significant differences from the DM model group and other FGF1 intervention groups. Cardiac catheter hemodynamic testing, CD31 immunohistochemical staining, and electron microscopy also confirmed the same conclusion. These results confirmed that the abnormalities, including myocardial dysfunction and perfusion impairment, could be suppressed to different extents by the twice weekly FGF1 treatments for 12 consecutive weeks (free FGF1, FGF1-nlip, and FGF1-nlip+UTMD), with the strongest improvements observed in the FGF1-nlip+UTMD group. In conclusion, the VVI and RT-MCE techniques can detect left ventricular systolic function and perfusion changes in DM rats, providing a more effective experimental basis for the early detection and treatment evaluation of DCM, which is of great significance for the prevention of DCM.

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Experimental study of epidermal growth factor and acidic fibroblast growth factor in the treatment of diabetic foot wounds

Abstract: Abstract. The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and acidic fibroblast growth factor (aFGF) on the healing of diabetic foot wounds.

Cited by 23 publications

References 40 publications

The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials

The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials

The Management of Diabetic Foot Ulcers Using the Wound Treatment Techniques of Modern Dressing: A Systematic Review

Assessment of the Preventive Effect Against Diabetic Cardiomyopathy of FGF1-Loaded Nanoliposomes Combined With Microbubble Cavitation by Ultrasound

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