Experimental Study of Hemodynamics in the Circle of Willis

Abstract

Background: The Circle of Willis (CoW) is an important collateral pathway of the cerebral blood flow. An experimental study of the cerebral blood flow (CBF) distribution in different anatomical variations may help to a better understanding of the collateral mechanism of the CoW.

Effect of Cerebral Flow Autoregulation Function on Cerebral Flow Rate Under Continuous Flow Left Ventricular Assist Device Support

“…The base values for blood vessel inner radiuses and lengths are taken from to estimate the resistances for the cerebral circulation. It should be noted that resistance of the blood vessels in Circle of Willis and cerebral circulation varies within a large range and significantly different values have been reported . Such large variations in the blood vessel lengths and inner radiuses cause a large variation in resistances.…”

“…and . Generally, blood flow is distributed uniformly and does not vary considerably in each section on the left and right sides unless there are significant anatomical variations or anomalies in the structure of the cerebral arteries . Therefore, in this study all of the blood vessels on the left and right sections are assumed to be identical.…”

Cardiovascular diseases and vulnerable plaques: data, modeling, predictions and clinical applications

“…Ventricle model papers included a review paper by Lee et al [ 21 ] and a mechanical analysis paper by Gan et al [ 22 ]. Experimental and numerical studies of the circle of Willis were presented by Zhu et al [ 23 ] and Ren et al [ 24 ]. Several papers presented new imaging techniques for better resolutions and/or applications [ 25 - 28 ].…”

Estudo Computacional da Hemodinâmica do Polígono de Willis

“…Segundo DEVAULT et al (2007), essa estrutura é a principal responsável por distribuir o fluxo sanguíneo cerebral. Além disso, segundo ZHU et al (2015), essa estrutura fornece importantes passagens colaterais de sangue em caso de oclusão ou estenose.…”

“…O polígono de Willis é composto pelas artérias vertebrais (VAs), artéria basilar (BA), artérias cerebrais anteriores (ACAs), artérias cerebrais médias (MCAs), artérias cerebrais posteriores (PCAs), artérias carótidas internas (ICAs), artéria comunicante anterior (ACoA) e artérias comunicantes posteriores (PCoAs). Entretanto, DEVAULT et al (2010), ZHU et al (2015) citam que cerca de 60% da população possua alguma variação no polígono de Willis e que essas possam estar associadas a fatores agravantes em caso de Ataque Vascular Cerebral (AVC) por oclusão ou estenose.…”