Experimental Study of Induced Inflammation in the Brazilian Boa (Boa constrictor constrictor)

Tucunduva, Maria Jose Albuquerque Pereira de Souza e; Borelli, Primavera; Silva, J.R.M.C.

doi:10.1053/jcpa.2001.0500

Cited by 19 publications

(9 citation statements)

References 9 publications

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“…This is also suggested by studies on chronic inflammation in snake and lizard tissues that can contain leukocytes for months and not macrophages, as it is typical for chronic inflammation in mammals (Albeiro et al. 2005; Montali 1988; Smith and Barker 1988; Tucunduva et al. 2001).…”

Section: Discussionmentioning

confidence: 78%

“…In the latter leukocytes are active in the first 1–3 days and die quickly after phagocytosis to be replaced by macrophages of blood origin in the following 3–4 days, which become the preponderant phagocytes of both acute and chronic inflammation (Ross and Odland 1968b; Agaiby and Dyson 1999). In wounded reptilian tissues, most leukocytes and only few macrophages immediately colonize the injuried area, but leukocytes persist with the increasing number of macrophages in the inflammatory area for long time (Smith and Barker 1988; Tucunduva et al. 2001).…”

Section: Discussionmentioning

confidence: 99%

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Ultrastructural features of the process of wound healing after tail and limb amputation in lizard

Alibardi

2010

Acta Zoologica

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Alibardi, L. 2010. Ultrastructural features of the process of wound healing after tail and limb amputation in lizard.-Acta Zoologica (Stockholm) 91: 306-318Wound healing and re-epitelization after amputation of tail and limb in lizard have been studied by electron microscopy to understand the cytological base of immunity to infection in this species. After 2 days post-amputation in both limb and tail stumps, numerous granulocytes are accumulated over the stump, and participate to the formation of the scab. Bacteria remain confined to the scab or are engulfed by leukocytes and migrating keratinocytes located underneath the scab. Bacteria are degraded within lysosomes present in these cells and are not observed among mesenchymal cells or in blood vessels of the regenerative blastema. Granulocytes, migrating keratinocytes, and later macrophages form an effective barrier responsible for limiting microbe penetration. The innate immunity in lizard is very effective in natural (dirty) condition and impedes the spreading of infection to inner tissues. While the complete re-epitelization of the tail stump underneath the scab requires 4-7 days, the same process in the limb requires 8-18 or more days post-amputation, depending from the level of amputation and the persistence of a protruding humerus or femurs on the stump surface. This delay produces the permanence of inflammatory cells such as granulocytes and macrophages in the limb stump for a much longer period than in the tail stump, a process that stimulates scarring.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Ultrastructural features of the process of wound healing after tail and limb amputation in lizard

Alibardi

2010

Acta Zoologica

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“…The inflammatory process in response to a foreign body has been studied in snakes and is characterized by heterophil and macrophage (azurophil) infiltration, followed by the participation of giant cells and granuloma formation (Tucunduva et al, 2001). The inflammatory response seen histologically in 8/12 transmitterimplanted snakes (grades 2, 3, and 4) corresponds with this description, varying from low-level diffuse cellular infiltrate seen in grade 2 snakes to organizing granulomatous reaction and exudation associated with mixed bacterial infection in grades 3 and 4.…”

Section: Discussionmentioning

confidence: 99%

Pathologic and Hematologic Responses to Surgically Implanted Transmitters in Eastern Massasauga Rattlesnakes (Sistrurus Catenatus Catenatus)

Lentini

Crawshaw

Licht

et al. 2011

Journal of Wildlife Diseases

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ABSTRACT:The study of secretive snakes, such as rattlesnakes, has benefited from the use of radiotelemetry. However, the principal assumption in telemetry studies is that the transmitter has no significant effect on the study animal. To test the validity of this assumption, the physiologic and pathologic effects of intracoelomic implants were examined in a group of 24 eastern massasauga rattlesnakes (Sistrurus catenatus catenatus) in a laboratory setting over a period of 58 wk between March 2005 and April 2006. Inflammation and infection were evaluated using gross examination, histopathology, bacteriology, hematology, and plasma protein electrophoresis. Inflammation and infection occurred despite careful surgical procedures and advanced veterinary care. Four of 12 (33%) snakes developed extensive inflammatory response to the transmitter and associated anaerobic and gram-negative bacterial infections. Another four (33%) snakes showed mild inflammatory responses without infection. Reaction to the transmitters was reflected in changes in values for heterophils, monocytes, alpha-1, and beta globulin levels. Some conclusions reached in field studies using implanted radiotransmitters in snakes may be invalid if the implant influences the behavior or survival of the subject. Advances in attachment methods and transmitter coating technology may prevent some of the adverse effects associated with surgically implanted transmitters.

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“…The early stages of the inflammatory response after injury are similar to that of mammals, with a large migration of heterophils to the area. However, these heterophils can last much longer at the site of injury than mammalian neutrophils (Tucunduva et al, 2001).…”

Section: Innate Immunitymentioning

confidence: 99%

Understanding the vertebrate immune system: insights from the reptilian perspective

Zimmerman

Vogel

Bowden

2010

Journal of Experimental Biology

357

344

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Summary Reptiles are ectothermic amniotes, providing the key link between ectothermic anamniotic fishes and amphibians, and endothermic amniotic birds and mammals. A greater understanding of reptilian immunity will provide important insights into the evolutionary history of vertebrate immunity as well as the growing field of eco-immunology. Like mammals, reptile immunity is complex and involves innate, cell-mediated and humoral compartments but, overall, there is considerably less known about immune function in reptiles. We review the current literature on each branch of the reptilian immune system, placing this information in context to other vertebrates. Further, we identify key areas that are prime for research as well as areas that are lagging because of lack of reagents in non-model systems.

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Experimental Study of Induced Inflammation in the Brazilian Boa (Boa constrictor constrictor)

Cited by 19 publications

References 9 publications

Ultrastructural features of the process of wound healing after tail and limb amputation in lizard

Ultrastructural features of the process of wound healing after tail and limb amputation in lizard

Pathologic and Hematologic Responses to Surgically Implanted Transmitters in Eastern Massasauga Rattlesnakes (Sistrurus Catenatus Catenatus)

Understanding the vertebrate immune system: insights from the reptilian perspective

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