The prefabricated structures have the advantages of high construction speed, energy efficiency, environmental friendliness, and low labor demand. At present, the connection of fabricated concrete structural components mainly relies on connecting the stressed steel bars of the prefabricated components using a variety of methods, and then casting concrete or grout at the joints. This requires a large quantity of wet work, and most studies on this topic focused on frame structures and shear wall structures. The research on frame-shear wall structures is still rare. To fill this gap, a new type of connecting prefabricated shear wall and prefabricated frame column in the assembled frame-shear structure by using concrete-filled steel tubs (CFST) keys is proposed with experimental study. This paper analyzes the differences in the mechanical properties and the failure modes of three kinds of structures , i.e. the wall and column connected by CFST keys, the wall and column connected by the CFST keys with concrete block placed between t hem, and the wall and column connected by the cast-in-place method. This paper also investigates the mechanical properties and failure modes of the first kind of structure when the failure of shear wall is caused by the CFST keys. The test results show tha t the CFST keys with the reinforced concrete block placed between them are superior to the cast-in-place structures in terms of wall-column connection mode, and the bearing capacity and ductility of the structure, while sharing similar initial stiffness of the structure.The CFST keys connection mode shows engineering feasibility and good seismic performance. When designing this type of connection, the strength of the CFST keys should be moderately controlled. If the strength level is too high, the shear resistance of the overall structure will decrease.