A method for predicting the fatigue life of triangular lattices is proposed in this paper by considering fatigue properties of single lattice struts. Fatigue tests of different sizes of lattice plates of aluminium alloy, and tests of single struts with different maximum fluctuating loads, have been conducted to validate this method. It is found that the struts in a triangular lattice break near to strut intersections, where stress and strain concentrations occur. Similar crack propagation paths were observed in different lattice plate specimens: the cracks grew at a 30° angle to the initial edge crack in the upper half of lattice plate. The mixed-mode fatigue crack propagation rate was also studied and expressed using an effective stress intensity factor. A size effect on the crack growth rate of triangular lattice plates was also observed: a fatigue crack will propagate slightly quicker in larger triangular plates than in smaller ones.