Experimental study of new derivatives of 3-hydroxypyridine as pharmacological agents for the correction of ischemic brain injury after intracerebral hemorrhage

Abstract

Introduction: Limiting the action of secondary injury factors can improve the prognosis in acute cerebral accidents. The aim of the investigation is to study the neuroprotective effects of 3-hydroxypyridine derivatives. Materials and methods: The study was performed in Wistar rats. An intracerebral hemorrhage (ICH) model was used. The animals were once administered intraperitoneally with the test drugs 1 hour before the surgery and on the 1st, 2nd and 3rd days. The registration of behaviors and condition of the animals on days 1, 3, 7 and 14 and the morphological examination of the brain were performed. Results and discussion: The use of the substances LKhT 4-97 and LKhT 11-02 in the treatment of experimental ICH had a positive effect on the survival rate of the animals and on the resolution rate of pathological signs (p<0.05). Clinical observations were confirmed by the results of analysis of the S100b brain damage marker and morphometry. The efficacy of LKhT 3-15 was largely comparable to that of the reference drug Mexidol. The efficacy of LKhT 01-09 was significantly inferior to that of the reference drug Mexidol. Differences in the neuroprotective effects of the studied substances are related to the metabolism of their various pharmacophores. A hypothetical mechanism for the induction of their neuroprotective effects has been proposed. Conclusion: Three of the four 3-hydroxypyridine derivatives under study have a neuroprotective effect, which is manifested in a more rapid resolution of pathological symptoms and less pronounced signs of neurodegeneration.

3-Hydroxypyridine and 3-(Hydroxymethyl)pyridine in the Synthesis of Salts of Aryldithiophosphonic Acids on the Basis of Monoterpenyl Alcohols

“…3-Hydroxypyridine and erythropoietin had positive neuroprotective effects on rats as hemorrhagic stroke models (6). As pharmacological agents for the correction of ischemic brain injury after intracerebral hemorrhage, derivatives of 3-hydroxypyridine such as 3-hydroxy-2-ethyl-6-methylpyridinium, Nacetylaminohexanoate, 4-aminobenzoate, Nacetylaminoacetate, and hydroxybutanedioate were used on rats (7,8). Вacterial purulent meningitis of rats caused by Streptococcus pneumoniae leads to edema of the brain, which is reduced when 2-ethyl-6-methyl-3hydroxypyridinium 2,6-dichlorophenyl (amino)phenylethanoic acid and bis(2-ethyl-6methyl-3-hydroxypyridinium) 2,6-dichlorophenyl (amino)phenylethanoic acid are administered to rats (9).…”