The MiniBooNE experiment was designed to perform a search for ν µ → ν e oscillations in a region of ∆m 2 and sin 2 2θ very different from that allowed by standard, threeneutrino oscillations, as determined by solar and atmospheric neutrino experiments. This search was motivated by the LSND experimental observation of an excess of ν e events in aν µ beam which was found compatible with two-neutrino oscillations at ∆m 2 ∼ 1 eV 2 and sin 2 2θ < 1%. If confirmed, such oscillation signature could be attributed to the existence of a light, mostly-sterile neutrino, containing small admixtures of weak neutrino eigenstates. In addition to a search for ν µ → ν e oscillations, MiniBooNE has also performed a search forν µ →ν e oscillations, which provides a test of the LSND two-neutrino oscillation interpretation that is independent of CP or CP T violation assumptions. This dissertation presents the MiniBooNE ν µ → ν e andν µ →ν e analyses and results, with emphasis on the latter. While the neutrino search excludes the two-neutrino oscillation interpretation of LSND at 98% C.L., the antineutrino search shows an excess of events which is in agreement with the twoneutrinoν µ →ν e oscillation interpretation of LSND, and excludes the no oscillations hypothesis at 96% C.L. Even though the neutrino and antineutrino oscillation results from MiniBooNE disagree under the single sterile neutrino oscillation hypothesis, a simple extension to the model to include additional sterile neutrino states and the possibility of CP violation allows for differences between neutrino and antineutrino oscillation signatures. In view of that, the viability of oscillation models with one or two sterile neutrinos is investigated in global fits to MiniBooNE and LSND data, with and without constraints from other oscillation experiments with similar sensitivities to those models. A general search for new physics scenarios which would lead to effective non-unitarity of the standard 3×3 neutrino mixing matrix, or mixing freedom, is also performed using neutrino and antineutrino data available from MiniBooNE.Thesis Supervisor: Janet M. Conrad Title: Professor of Physics Acknowledgments I owe this work to my advisor, Janet Conrad. Janet, you have been not only an unending source of inspiration for me these past five years, but also the reason I joined neutrino physics in the first place. Our very first meeting during the Columbia graduate student open house in 2005 was what introduced me to the excitement of neutrinos, while our interaction since then has made me appreciate the richness of this field. Thank you for the opportunity of becoming your advisee, and for your guidance and dedication over these past five years.I can't express how grateful I am to all the people I've worked most closely with during these past five years: I must begin with Michel Sorel, who has been like an older brother to me since the summer of 2005, introducing me to his work on sterile neutrinos and supporting me as I followed in his footsteps; Mike Shaevitz, for looking o...