Experimental study of sound scattering by elastic spheroids

Bao, Xiaojun; Überall, H.; Niemiec, Jan M.

doi:10.1121/1.419940

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…The microfluidic devices are easily fabricated, and the ultrasound hardware can be integrated into a wide variety of other microfluidic-based cell characterization systems, potentially enabling a multiparameter analysis of the cells to extract additional cellular details to further enhance cell classification. For example, ultrasound is sensitive to cell morphology 54 , 55 , a feature cannot be ascertained using traditional flow cytometry characterization systems. Adding a laser would enable simultaneous photoacoustic measurements.…”

Section: Discussionmentioning

confidence: 99%

Sizing biological cells using a microfluidic acoustic flow cytometer

Strohm

Gnyawali

Sebastian

et al. 2019

Sci Rep

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We describe a new technique that combines ultrasound and microfluidics to rapidly size and count cells in a high-throughput and label-free fashion. Using 3D hydrodynamic flow focusing, cells are streamed single file through an ultrasound beam where ultrasound scattering events from each individual cell are acquired. The ultrasound operates at a center frequency of 375 MHz with a wavelength of 4 μm; when the ultrasound wavelength is similar to the size of a scatterer, the power spectra of the backscattered ultrasound waves have distinct features at specific frequencies that are directly related to the cell size. Our approach determines cell sizes through a comparison of these distinct spectral features with established theoretical models. We perform an analysis of two types of cells: acute myeloid leukemia cells, where 2,390 measurements resulted in a mean size of 10.0 ± 1.7 μm, and HT29 colorectal cancer cells, where 1,955 measurements resulted in a mean size of 15.0 ± 2.3 μm. These results and histogram distributions agree very well with those measured from a Coulter Counter Multisizer 4. Our technique is the first to combine ultrasound and microfluidics to determine the cell size with the potential for multi-parameter cellular characterization using fluorescence, light scattering and quantitative photoacoustic techniques.

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Section: Discussionmentioning

confidence: 99%

Sizing biological cells using a microfluidic acoustic flow cytometer

Strohm

Gnyawali

Sebastian

et al. 2019

Sci Rep

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show abstract

“…For example, the scattering of the sound field by hard or soft, prolate or oblate spheroids are considered in [1][2][3][4][5][6][7]. The results of the scattering of sound permeable and elastic spheroids are studied in the works [8][9][10][11][12]. Analytical description of the acoustic field scattered by inhomogeneous elastic spheroid is obtained in [13].…”

Section: Introductionmentioning

confidence: 99%

The scattering of the sound field by thin unclosed spherical shell and ellipsoid

2016

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In this paper the result of solution of the axisymmetric problem of the scattering of sound field by unclosed spherical shell and a soft prolate ellipsoid of rotation is presented. Spherical radiator is located in a thin unclosed spherical shell as the source of acoustic field. The equation of the spheroidal boundary is given in spherical coordinates. Scattered pressure field is expressed in terms of spherical wave functions. Using corresponding theorems of addition and assuming small eccentricity of ellipse, the solution of boundary value problem is reduced to solving dual equations with Legendre's polynomials, which are converted to infinite system of linear algebraic equations of the second kind with completely continuous operator. Numerical results are given for various values of the parameters of the problem.

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“…The propagation of the sound field by hard or soft, prolate or oblate spheroids using different techniques is considered in [5][6][7][8][9][10][11][12]. The results of the sound field propagation on permeable and elastic spheroids are studied in [13][14][15][16][17]. The analytical description of the acoustic field scattered by a inhomogeneous elastic spheroid is obtained in [18].…”

Section: Introductionmentioning

confidence: 99%

Propagation of the sound wave by an unclosed spherical shell and a penetrable ellipsoid

Шушкевич

2016

ZN PRz Mechanika

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In this paper the result of solution of axisymmetric problem of propagation of sound wave by an unclosed spherical shell and a penetrable ellipsoid of rotation is presented. A spherical radiator is located in a thin unclosed spherical shell as a source of acoustic field. The equation of the spheroidal boundary is given in spherical coordinates. A scattered pressure field is expressed in terms of spherical wave functions. Using corresponding additional theorems the solution of boundary value problem is reduced to solving of dual equations in Legendre's polynomials, which are converted to infinite system of linear algebraic equations of the second kind. The formula for calculation of the far field and numerical results for different values of parameters are obtained.

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Experimental study of sound scattering by elastic spheroids

Cited by 9 publications

References 11 publications

Sizing biological cells using a microfluidic acoustic flow cytometer

Sizing biological cells using a microfluidic acoustic flow cytometer

The scattering of the sound field by thin unclosed spherical shell and ellipsoid

Propagation of the sound wave by an unclosed spherical shell and a penetrable ellipsoid

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