Experimental Study of the Action of Cox-2 Selective Nonsteroidal Anti-Inflammatory Drugs and Traditional Anti-Inflammatory Drugs in Bone Regeneration

Tiseo, Bruno Camargo; Namur, G.N.; Paula, Emygdio José Leomil de; Júnior, Rames Mattar; Oliveira, Cláudia de

doi:10.1590/s1807-59322006000300007

Cited by 16 publications

(14 citation statements)

References 26 publications

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“…Some animal studies have investigated the effects of ketoprofen, meloxicam, and diclofenac on bone healing, and some of these studies showed that these drugs impair the bone healing process, whereas others showed that these drugs did not affect the healing process [7,[39][40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model

İnal

Kabay

Çaycı

et al. 2014

Injury

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Section: Discussionmentioning

confidence: 99%

Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model

İnal

Kabay

Çaycı

et al. 2014

Injury

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“…Three important outcomes commonly used to assess bone healing were analyzed: biomechanical properties (maximum force to break, stiffness, and work to failure), micro CT, and histomorphometric measurements. NSAID administration had a negative effect on the biomechanical properties in different animal models of the included studies (10,12,18,19,47,(50)(51)(52)(53)(54)(55)(56)(57)(58). However, the results for histomorphometric assessments did not show a difference (Tables 3). Depending on the type of NSAID, they are known to inhibit both COX isoforms.…”

Section: Discussionmentioning

confidence: 92%

Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

Al-Waeli

Reboucas²,

Mansour

et al. 2020

Preprint

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Background: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis have yet been conducted to on the subject. Such work is important as it can identify the key histomorphometric and biomechanics characteristics during the process of fracture healing and provide comparative information regarding different factors that may affect this process after NSAID administration.Methods: We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to August 1, 2017 for articles on fractured bone healing in animal models in which NSAID were administered.Results: Out of 5,818 articles screened, 45 were included and three common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (µ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerningrandomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals.Conclusion: The findings suggest that NSAID should be administered with caution in patients with bone fractures or in those who undergo certain orthopedic surgical procedures until prospective human clinical studies can be conducted.Systematic review registration: the protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

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“…The forest plot displays the standard mean differences (SMDs) Hedges' g, 95% confidence interval. The diamond indicates the global (overall) estimation and its 95% confidence interval NSAID administration had a negative effect on the biomechanical properties in different animal models of the included studies [10,12,18,19,48,[51][52][53][54][55][56][57][58][59]. However, the results for histomorphometric assessments did not show a difference (Table 3).…”

Section: Discussionmentioning

confidence: 98%

Non-steroidal anti-inflammatory drugs and bone healing in animal models—a systematic review and meta-analysis

et al. 2021

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Background Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis of animal studies that investigate the effect of NSAID administration on bone fracture healing. Objective of this study is to conduct a systematic review and meta-analysis to estimate the effect of NSAIDs administration on bone healing biomechanical and histomorphometric measurements in different animal models after bone fracture surgery. Methods We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to 1 February 2021 for articles on fractured bone healing in animal models in which NSAID were administered. Results Out of 6732 articles screened, 47 were included and 3 common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (μ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerning randomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals. Conclusion The findings demonstrated that NSAIDs administration decreased the biomechanical properties of healing bones after fracture surgery in comparison to the control group. Moreover, different effect on certain outcomes was detected among different sites, sex of the animals, and the time of assessment. Trial registration Protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

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Experimental Study of the Action of Cox-2 Selective Nonsteroidal Anti-Inflammatory Drugs and Traditional Anti-Inflammatory Drugs in Bone Regeneration

Cited by 16 publications

References 26 publications

Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model

Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model

Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

Non-steroidal anti-inflammatory drugs and bone healing in animal models—a systematic review and meta-analysis

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