The hydrothermal Mo-U deposits of the Strel'tsovka ore field, unique in reserves, are localized in the Late Mesozoic caldera of the same name. The consideration of geochemical processes that controlled uranium transfer by ore-bearing fluids and its precipitation in orebodies has shown that a nonstationary temperature distribution could have exerted a substantial effect on ore formation. The temperature field in the Strel'tsovka caldera, which was caused by a shallow-seated magma chamber that existed beneath the caldera by the onset of the ore stage, was simulated by mathematical modeling. A one-dimensional nonstationary model of conductive heat transfer taking into account the latent heat of magmatic melt crystallization was used. The problem was solved with the finite difference method. It has been established that, at optimal parameters of the model, the magma chamber would have completely crystallized in 56 ka; the maximum estimate is 133 ka. Three million years after emplacement of the granitic intrusion, the related thermal anomaly in the upper crust should have disappeared. The results obtained indicate that granitic melt of this chamber could not have been a source of uranium-bearing solutions that formed deposits 5 Ma after the cessation of magmatic activity.