In order to analyze the influence degree of different factors on gas extraction radius, on the basis of coal seam gas flow theory and elastic mechanics, considering the influence of coal seepage rate change on gas flow, the COMSOL Multiphysics numerical simulation software is secondarily developed by using the stress-seepage coupling mathematical model of coal and rock containing gas. Taking coal seam No.2 of Juji Coal Mine as an example, the effective extraction radius under different extraction negative pressure, extraction borehole diameter, extraction time, and initial permeability of coal seam are simulated, respectively. Then, the orthogonal test method is used to design different calculation schemes, and the effective extraction radius is used as the judgment index. The simulation software is used to calculate the effective extraction radius corresponding to different influencing factors. SPSS statistical software is used to analyze the parameters. The multivariate linear regression equation of the influencing factors of the effective extraction radius is obtained, and the multivariate linear regression model is established. The results show that the negative pressure of extraction has little effect on the effective extraction radius; the effective extraction radius gradually expands with the increase of extraction time and extraction aperture, but it has certain timeliness. The initial permeability of the coal seam has a great influence on the effective extraction radius. The influence degree of different influencing factors from large to small is the initial permeability of coal seam, extraction time, borehole diameter, and extraction negative pressure. Therefore, the key to improving the effectiveness of gas extraction is to increase the initial permeability of the coal seam before preextraction, ensure sufficient extraction time, appropriately increase the borehole diameter, and improve the negative pressure of extraction. Finally, the gas flow rate is used for a field test, and the measured results are basically consistent with the simulation results, which proves the correctness of the mathematical model of gas-containing coal and the feasibility of using numerical simulation methods to study the effective extraction radius of coal seams.