Mine hoisting systems have been widely used in coal mine industries. Due to a series of uncertain faults in the steel guide, serious vibrations will be excited during the operation of the machine, which will seriously influence the stability and safety of the system. In this paper, a semi-active vibration control strategy based on magnetorheological dampers was innovatively proposed. Firstly, a reasonable simplified dynamic model of mine hoisting system was established. Secondly, the simulation results from the virtual prototype model were used to verify the rationality of the established dynamic model. Then, a fuzzy skyhook damping semi-active control scheme based on magnetorheological dampers was designed. Finally, the availability of this vibration control scheme was verified by the Adams/Simulink co-simulation technique. The root mean square (RMS), mean and maximum values of the horizontal vibration acceleration of the container were reduced by 47.32%, 22.50% and 35.39%, respectively. The fuzzy skyhook damping semi-active control strategy of good stability can well suppress the horizontal vibrations of the mine hoisting system.INDEX TERMS Semi-active control, fuzzy skyhook damping control, magnetorheological dampers, mine hoisting systems.