Bridging plugging is the most used method of plugging in unconventional oil reservoirs, and many factors affect the effect of bridging and plugging. Since the laboratory cannot simulate the actual leakage size of the lost formation and the corresponding leakage plugging process at the drilling site, the laboratory experiment results cannot reflect the actual leakage plugging construction effect. Aiming at the problem of frequent fracture leakage during drilling in Chepaizi block, Xinjiang, China, this paper proposes a set of machine learning methods based on a neural network. Three types of factors and 14 parameters with a strong correlation with the leakage control effect were screened out. Three categories of factors include construction parameters, choice of plugging material, and fluid properties of the carrier fluid. The training was carried out based on the collected field data, the appropriate activation function was set, and the deep well network structure was optimized. By improving the field plugging measures in the later period, the model was verified by these actual cases, and the results showed that the established model produced the highest
R
2
of 0.974, has a good fit, and predicts well.