When an earthquake occurs, the seriously damaged in ll walls have an adverse impact on frame due to in ll-frame interaction. Some codes suggest that the in ll walls should be isolated from frames or use a exible connection construction, but these applications may reduce OOP (out-of-plane) stability and increase the risk of OOP collapse. In this study, a new type of exible connection is adopted for the opening in ll wall-RC frame structures. The in ll wall-RC frame structures with rigid connection, traditionally exible connection and new type of exible connection in this context were examined experimentally and numerically, and their IP and OOP after IP (in-plane) damage seismic performance were compared. As a result of the study, the new type of exible connection effectively reduces IP damage of the in ll walls and undesirable in llframe interaction. Compared with rigid and traditional connection, the frame with new exible connection improves the energy dissipation capacity by about 37.8% and 3.5%, respectively. At the same time, the OOP strength and stiffness of the new exible connection increased by 119.8% and 104.2% in the same prior IP drift ratio than that of traditional exible connection. It is thought that the steel cable structure can improve the restraint of frames on in ll walls, which is bene cial to development of OOP horizontal arch mechanism.