Experimental study on the biocompatibility and osteogenesis induction ability of PLLA/DDM scaffolds

Feng, Song; Li, Ruipiao; Wang, Zhiying

doi:10.1007/s10266-021-00683-4

Cited by 2 publications

(4 citation statements)

References 44 publications

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“…Depending on the chemical treatment, the size and spatial porous structure of ATDM granules can be enlarged, resulting in increased porosity from 3 up to 20% [50]. The porous structure of ATDM granules increases their wettability and retains blood contents from host tissues including water, proteins, and minerals [51,52], that provides an optimal environment for the adhesion and proliferation of osteogenic cells. In fact, Hap still remains in the ATDM granules and the chemical composition and porous structure allow the release of growth factors [28,48,49].…”

Section: Chemical Composition and Morphological Aspects Of Dentin-der...mentioning

confidence: 99%

“…In fact, Hap still remains in the ATDM granules and the chemical composition and porous structure allow the release of growth factors [28,48,49]. Micro-scale porous surfaces stimulate the adhesion, proliferation, and differentiation of osteogenic cells leading to enhanced bone healing [51,53,54]. However, micro-scale pores at 1-3 μm do not allow cell infiltration and ingrowth or neither the formation of blood vessels.…”

Section: Chemical Composition and Morphological Aspects Of Dentin-der...mentioning

confidence: 99%

“…A variable period of time required for resorption of dentin graft has been reported, and histologic studies have shown a characteristic depiction of graft particles encased in newly formed bone [8,60]. A lack of regular resorption time affects the predictably of the dentin- The porous structure of ATDM granules increases their wettability and retains blood contents from host tissues including water, proteins, and minerals [51,52], that provides an optimal environment for the adhesion and proliferation of osteogenic cells. In fact, Hap still remains in the ATDM granules and the chemical composition and porous structure allow the release of growth factors [28,48,49].…”

Section: In Vivo Evidence Of Bone Healingmentioning

confidence: 99%

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Tooth-Derived Matrix Granules for Enhanced Bone Healing: Chemical Composition, Morphological Aspects, and Clinical Outcomes

et al. 2022

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Bone grafting has increasingly been used in surgical procedures for enhanced bone augmentation. Tooth-derived graft material has received considerable attention due to its chemical composition and autogenous source that can improve bone tissue healing. The main aim of this study was to provide a short and comprehensive review on the chemical composition, morphological aspects, and clinical outcomes of bone grafting using tooth-derived matrix granules. Dentin tissue has a chemical composition similar to that on bone tissues regarding the presence of hydroxyapatite, type I collagen, and different growth factors. Dentin-matrix granules are often processed at well-controlled size ranging from approximately 300 up to 1300 µm, while maintaining porosity and organic content. In addition, a dense collagen fiber network is still present after the milling and chemical treatment of dentin granules. Thus, dentin-matrix granules can improve the bone healing process considering their chemical composition, porous structure, and adequate size. However, further in vivo and in vitro studies should be performed taking into consideration different demineralization procedures, remnant organic content, porosity, and granule size.

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Section: Chemical Composition and Morphological Aspects Of Dentin-der...mentioning

confidence: 99%

Section: Chemical Composition and Morphological Aspects Of Dentin-der...mentioning

confidence: 99%

Section: In Vivo Evidence Of Bone Healingmentioning

confidence: 99%

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Tooth-Derived Matrix Granules for Enhanced Bone Healing: Chemical Composition, Morphological Aspects, and Clinical Outcomes

et al. 2022

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“…The dentin matrix, which contains collagen proteins and many non-collagen proteins (NCPs) associated with mineralization, is a type of autologous acquisition biomineral material [12][13][14][15] . It plays a significant role in the osteogenesis and odontogenic lineage differentiation of mesenchymal cells and can be used for repairing hard tissue defects [16][17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

et al. 2023

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Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural hard tissue structure as a template, constructing an engineered tissue repair module is an important scheme to realize the functional regeneration and repair of maxillofacial hard tissue. Here, inspired by the biomineralization process, we constructed a composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) and dentin matrix (TDM). The dynamic network composed of Ca2+·COO− coordination and ACPs made the hydrogel loaded with TDM, and exhibited self-repairing ability and injectability. The mechanical properties of PAA-CMC-TDM can be regulated, but the functional activity of TDM remains unaffected. Cytological studies and animal models of hard tissue defects show that the hydrogel can promote the odontogenesis or osteogenic differentiation of mesenchymal stem cells, adapt to irregular hard tissue defects, and promote in situ regeneration of defective tooth and bone tissues. In summary, this paper shows that the injectable TDM hydrogel based on biomimetic mineralization theory can induce hard tissue formation and promote dentin/bone regeneration.

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Experimental study on the biocompatibility and osteogenesis induction ability of PLLA/DDM scaffolds

Cited by 2 publications

References 44 publications

Tooth-Derived Matrix Granules for Enhanced Bone Healing: Chemical Composition, Morphological Aspects, and Clinical Outcomes

Tooth-Derived Matrix Granules for Enhanced Bone Healing: Chemical Composition, Morphological Aspects, and Clinical Outcomes

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

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