Experimental study on the circulatory effects of 2-(2,6-dichlorophenylamino)-2-imidazolinehydrochloride in man

Merguet, P; Heimsoth, V.; Murata, Tōru; Bock, K. D.

doi:10.1007/bf00463077

Cited by 17 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently there was a slight decrease below baseline. A biphasic pattern of left ventricular systolic pressure, has also been described after intravenous administration of clonidine, another imidazoline derivative [Merguet et al, 1968;Tangri et al, 19771. It must be pointed out, however, that in two additional experiments in which we infused 10 p,g kg-' clonidine over a period of 2 min, the increase in arterial blood pressure (40 and 35%) was not only greater, but also persisted much longer (over 15 min).…”

mentioning

confidence: 98%

The effects of cibenzoline, an imidazoline derivative with antiarrhythmic properties, on systemic hemodynamics and regional myocardial performance

Verdouw

Hartog

Scheffer

et al. 1982

Drug Development Research

View full text Add to dashboard Cite

The effects of increasing doses of cibenzoline (-2(2,2-diphenylcyclopropyl)-2-imidazoline, Cipralan), a new compound with antiarrhythmic properties, on systemic hemodynamics and regional myocardial performance were studied in anesthetized pigs. Doses of 0.5-2.0 mg kg-I i.v. produced a 10-15% prolongation of the PP' interval, and a dose-dependent increase (up to 60%) in QRS width, with only minor changes in PQ and ST length. Stroke volume decreased dose dependently (20-35%) immediately after drug administration, due to a decrease in myocardial contractility and an increase in systemic vascular resistance. Renal blood flow was unchanged, despite the decrease in cardiac output. Coronary blood flow decreased, while myocardial O2 extraction was unchanged. Hence myocardial 0, consumption decreased parallel to the decrease in flow, a consequence of the lowered myocardial 0, demand. Studies with radioactively labeled microspheres revealed that the decrease in myocardial blood flow was equally distributed over the transmural layers.

show abstract

mentioning

confidence: 98%

The effects of cibenzoline, an imidazoline derivative with antiarrhythmic properties, on systemic hemodynamics and regional myocardial performance

Verdouw

Hartog

Scheffer

et al. 1982

Drug Development Research

View full text Add to dashboard Cite

show abstract

“…In fact, during the intravenous administration of clonidine, significant vasoconstriction occurs (22). The flow of the skin vessels may be temporarily reduced 50-60 % (14). The vasoconstriction subsides within a few minutes and is followed by dilatation (22).…”

Section: Discussionmentioning

confidence: 99%

Clonidine in the treatment of vibration-induced white fingers.

Pyykko¹,

Färkkilä²

1982

Scand J Work Environ Health

View full text Add to dashboard Cite

The effect ofclonidine, a centrally acting drug diminishing the sympathetic activity of peripheral nerves, was examined in a double-blind study of 60 forest workers with vibration-induced white fingers. Clonidine was administered in daily doses of 0.450 mg or 0.100 mg during 30 d. The results were evaluated from a self-administered questionnaire. No significant differences were discerned between the active and placebo groups in respect to either recovery time after an attack or frequency of attacks. Neither did the subjective evaluation of the overall effectiveness of the drug show any differences between the groups. In two subjects clonidine provoked Raynaud's phenomenon, which subsided after the cessation of treatment. The recording of finger pulse plethysmography for two subjects treated with 0.450 mg of clonidine daily revealed comparatively well preserved vascular reflexes, whereas sympathetic mass reflexes such as galvanic skin response were almost absent.

show abstract

“…The acute haemodynamic effects of this compound in man are an initial decline in both cardiac output and total peripheral resistance (Onesti, Schwartz, Kim, Swartz & Brest, 1969). Acute experiments also showed reductions in catecholamine excretion (Merguet, Heimsoth, Murata & Bock, 1968), plasma renin activity and aldosterone excretion (Hokfelt, Hedeland & Dymling, 1970). In one study, blood volume did not change during oral treatment with clonidine for several days (Merguet et a/., 1968).…”

Section: Introductionmentioning

confidence: 99%

“…Acute experiments also showed reductions in catecholamine excretion (Merguet, Heimsoth, Murata & Bock, 1968), plasma renin activity and aldosterone excretion (Hokfelt, Hedeland & Dymling, 1970). In one study, blood volume did not change during oral treatment with clonidine for several days (Merguet et a/., 1968). Clonidine has an action span of 4-6 h (Onesti et a/., 1969; Hoobler & Sagastume, 1971).…”

Section: Introductionmentioning

confidence: 99%

Haemodynamic and Endocrine Changes during Antihypertensive Treatment with Clonidine and its Derivative St 600

et al. 1976

View full text Add to dashboard Cite

1.The cardio-renal haemodynamic and endocrine effects of the anti-hypertensive agents 2-(2,6dichlorophenylamine)-2-imidazoline hydrochloride (clonidine, St 155) and 2-(5-fluor-o-toluidine)-2imidazoline hydrochloride (St 600) were investigated in twelve patients with essential hypertension.2. The anti-hypertensive action of both compounds was similar and was accompanied by a reduction in heart rate and in cardiac output, total peripheral resistance being unchanged. There was no alteration in renal blood flow and glomerular filtration rate, and renal vascular resistance showed a significant decrease. Blood volume and plasma renin concentration did not change significantly. An inverse relation between changes in plasma volume and plasma aldosterone concentration was observed. In the face of similar reductions in blood pressure, no differences were observed between systemic and renal haemodynamic and endocrine responses after clonidine and St 600.

show abstract

Experimental study on the circulatory effects of 2-(2,6-dichlorophenylamino)-2-imidazolinehydrochloride in man

Cited by 17 publications

References 11 publications

The effects of cibenzoline, an imidazoline derivative with antiarrhythmic properties, on systemic hemodynamics and regional myocardial performance

The effects of cibenzoline, an imidazoline derivative with antiarrhythmic properties, on systemic hemodynamics and regional myocardial performance

Clonidine in the treatment of vibration-induced white fingers.

Haemodynamic and Endocrine Changes during Antihypertensive Treatment with Clonidine and its Derivative St 600

Contact Info

Product

Resources

About