Experimental Substantiation of Shape Forming and Sanitation Function of Cement Spacers at Treatment of Hip Periprosthetic Osteomyeliti

Abstract

Degree and terms of acetabular bone structures reparation, indices of total and local immunity were evaluated in experiment (12 dogs with osteomyelitis). In the main group surgical treatment consisted of proximal femur resection with implantation of articulating spacer. In control group resection arthroplasty was performed. Roentgenologic and morphologic data showed marked reparative regeneration of acetabular bone structures under the influence of inserted spacer at terms up to 16 weeks. At application of spacers immunologic picture was characterized by rapid restoration of pro- and anti-inflammatory cytokines balance as well as by the absence of immunomodulatory effect on phagocytic link of the immune system.