Experimental Testing of Antianginal Drugs in Animals

Raberger, G.

doi:10.1007/978-3-642-69524-7_4

Handbook of Experimental Pharmacology

1985

DOI: 10.1007/978-3-642-69524-7_4

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Experimental Testing of Antianginal Drugs in Animals

G. Raberger¹

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1986

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Propranolol Ameliorates Exercise‐induced Regional Myocardial Dysfunction in Dogs

Mayer¹,

Krumpl²,

Schneider³

et al. 1986

Clin Exp Pharma Physio

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The effects of propranolol (0.5 mg/kg) on exercise-induced regional myocardial dysfunction were investigated in an animal model with limited coronary reserve. Limited coronary reserve was accomplished in conscious, chronically instrumented dogs by external filling of a hydraulic cuff occluder placed on a coronary vessel which did not impair resting myocardial function but induced severe dysfunction during treadmill exercise. Propranolol led to a distinct reduction of heart rate, myocardial contractility and systolic blood pressure, thereby ameliorating exercise-induced regional myocardial dysfunction.

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Propranolol Ameliorates Exercise‐induced Regional Myocardial Dysfunction in Dogs

Mayer¹,

Krumpl²,

Schneider³

et al. 1986

Clin Exp Pharma Physio

Self Cite

View full text Add to dashboard Cite

show abstract

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Experimental Testing of Antianginal Drugs in Animals

Cited by 1 publication

References 161 publications

Propranolol Ameliorates Exercise‐induced Regional Myocardial Dysfunction in Dogs

Propranolol Ameliorates Exercise‐induced Regional Myocardial Dysfunction in Dogs

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