Experimental therapeutic intralymphatic studies

Liebner, Edwin J.; Haas, Richard E.; Leroy, Elie P.

doi:10.1002/1097-0142(196507)18:7<827::aid-cncr2820180709>3.0.co;2-9

Cited by 6 publications

References 7 publications

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Effect of ionizing irradiation on normal lymphatic vessels and lymph nodes

Sherman

O’Brien

1967

Cancer

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Forty dogs were divided into five groups: (A) control, (B) 1000 rads, (C) 2400 rads, (D) 3000 rads and (E) 3600 rads. The medial aspect of one pelvic limb was irradiated through a port measuring 12 × 8 cm. Prior to irradiation and at intervals after, the pelvic limb lymphatics and popliteal lymph node were visualized by an indirect technique of lymphangiography. The afferent and efferent lymphatic vessels in the control and treated animals remained essentially unchanged except in four animals. These four animals, one in the 2400 rad group and three in the 3600 rad group, exhibited rupture of the afferent lymphatic vessels at the junction of irradiated and nonirradiated tissues several months after treatment. All treated animals showed a marked permanent decrease in size of lymph nodes several months after treatment. There was no evidence of lymphatic obstruction in any group. The authors conclude that ionizing irradiation appears to have little effect on lymphatic vessels. As reported previously, the lymph node undergoes fibrosis without obstruction.

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Effect of ionizing irradiation on normal lymphatic vessels and lymph nodes

Sherman

O’Brien

1967

Cancer

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Histologic effects of endolymphatic radiotherapy

Lord

Kinmonth

1969

Cancer

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Lipid preparations labelled with 32p and 131I were infused directly into lymphatic vessels draining to Vx2 tumor‐involved lymph nodes in the rabbit. The animals were killed from 1 to 250 days later, at which time the target lymph nodes and other viscera were examined. The initial response of the infused lymph nodes was characterized by a rapid necrosis of all cells within the physical range of the isotope. Cellular debris was then removed leving little more than the original fibrous framework of the node. Progressive fibrosis followed, eventually forming a contracted sclerotic mass, unrecognizable as a normal node. The lungs, liver, spleen, bone marrow, kidneys, ureters, and bladder were also examined. No specific effects of radiation were detected in these organs. The technique proved safe for organs while achieving massive oncolysis in the target lymph nodes.

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Intralymphatic Therapy

Jantet¹

1969

Recent Results in Cancer Research

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Experimental therapeutic intralymphatic studies

Cited by 6 publications

References 7 publications

Effect of ionizing irradiation on normal lymphatic vessels and lymph nodes

Effect of ionizing irradiation on normal lymphatic vessels and lymph nodes

Histologic effects of endolymphatic radiotherapy

Intralymphatic Therapy

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