Experimental thrombosis model induced by free radicals. Application to aspirin and other different substances

Adenoviral TNF-α gene therapy and radiation damage tumor vasculature in a human malignant glioma xenograft

“…31 Free radical production following exposure to radiation 32 and other agents such as melphalan, has also been shown to cause thrombosis of tumor vasculature. 33 In this study, the vascular thrombosis that was observed following combined treatment could have resulted from either endothelial damage with activation of procoagulants or direct activation of coagulation mechanisms.…”

Role of Oxidized Lipids in Atherosclerosis

“…Increased formation of MDA has been associated with arachidonic acid metabolism and platelet aggregation (Marie, 1979;Macfarlane et al, 1977;Garelnabi et al 2008;Garelnabi et al 2010). Experimental studies have shown that free radicals promote platelet aggregation and thrombosis and chain breaking antioxidants, such as vitamin E, inhibit or delay arterial thrombogenesis (Ikeda et al, 1994;Jourdan et al, 1995 The autoxidation of polyunsaturated lipids is an irreversible destructive process; and in tissues it may be associated with accelerated cell aging and premature cell death. Because such biological autoxidation is essentially slow process, the quantitative measurement of susceptibility to oxidation requires standard experimental stress conduction (Dildar et al, 1998).…”

Blocking of Platelets or Intrinsic Coagulation Pathway–Driven Thrombosis Does Not Prevent Cerebral Infarctions Induced by Photothrombosis

“…Similarly, Rose Bengalinduced thrombosis of mesenteric arterioles did not respond to antiplatelet therapy with acetylsalicytic acid. 28 In the absence of functional platelets, occluding thrombi could potentially be formed by the plasmatic coagulation cascade. We could show, however, that targeting FXa, the key protease of plasmatic coagulation by low-molecularweight heparin likewise had no influence on infarct development in the PT model.…”