Experimental Transplantation of Teeth to Simulated Maxillary Alveolar Clefts

Abstract

A total of 14 teeth were transplanted to simulated alveolar clefts in 5 monkeys. Autogenous cancellous bone was grafted to the cleft together with the tooth in ten instances. Healing processes were observed 216 or 271 days postoperatively. Another group of four teeth were transplanted in the cleft areas 133 days after bone grafting. These teeth were observed for 138 days before sacrifice. Radiological and histological findings support previous reports on adverse effects to dental tissues when placed in direct contact with fresh transplanted bone. Root resorption and ankylosis occurred to a large extent. Establishment of a normal periodontal membrane could, however, be observed when the tooth was transplanted to an area grafted 4 months previously. An interval before tooth transplantation allowing the cancellous graft to organize and bone to remodel seems to be indicated.

Orthodontic Treatment with Tooth Transplantation for Patients with Cleft Lip and Palate

“…Tooth transplantation recently has become more common in clinical treatment, and significantly higher success rates (>95%) have been reported (Akiyama et al, 1998; Reich, 2008). Previous studies reported encouraging findings for tooth transplantation (Slagsvold and Bjercke, 1978; Stenvik et al, 1989; Andreasen et al, 1990). Autogenous tooth transplantation was applied successfully to the region of upper missing anterior teeth without immunologic problems (Slagsvold and Bjercke, 1978).…”

An interview with Ewa Czochrowska

“…In two of those patients, premolar transplantation was performed 1-1.5 years after bone grafting, so this is also possible. Stenvik 5 has published the results from animal experiments and has recommended postponing tooth transplantation, if planned, at least 4 months after bone grafting. Tooth transplantation into freshly grafted bone can lead to root resorption of the donor.…”

Combined Surgical/Orthodontic Treatment and Autotransplantation of a Premolar in a Patient with Unilateral Cleft Lip and Palate

“…Evidence for the success of transplanting premolars, and even molars, to the incisor region has been presented by others (e.g., Natiella et al, 1970;Kristerson and Lagerström, 1991). Premolar transplantation to the site of a cleft is not such a well-known procedure, but results in an animal experimental study by Stenvik et al (1989) and case reports by Hillerup et al (1987) and Hamamoto et al (1998) indicate that this procedure can be successful. Stenvik et al (1989) transplanted 14 teeth to simulated alveolar clefts in five monkeys.…”

“…Premolar transplantation to the site of a cleft is not such a well-known procedure, but results in an animal experimental study by Stenvik et al (1989) and case reports by Hillerup et al (1987) and Hamamoto et al (1998) indicate that this procedure can be successful. Stenvik et al (1989) transplanted 14 teeth to simulated alveolar clefts in five monkeys. In cases in which the transplantation was done at the same time as the autologous grafts were placed, root resorption and ankylosis occurred to a large extent.…”

“…In cases in which the transplantation was done at the same time as the autologous grafts were placed, root resorption and ankylosis occurred to a large extent. However, when 4 months elapsed between placement of the graft and the autotransplantation, a normal periodontal membrane developed (Stenvik et al, 1989). Hillerup et al (1987) reported on four patients in which three premolars and one ectopic lateral incisor were transplanted to the bone graft.…”