Experimental use of new absorbable tracheal stent

Schopf, Luciano Ferraz; Fraga, José Carlos Soares de; Porto, Rodrigo Hennemann; Santos, Luís Alberto dos; Marques, Douglas Ramos; Sanchez, Paulo R; Meyer, Fabíola Schons; Ulbrich, Jane Maria

doi:10.1016/j.jpedsurg.2017.11.038

Cited by 13 publications

(15 citation statements)

References 22 publications

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Section: Medicinaunclassified

“…El trabajo desarrollado por Schopf et al evalua los stents en forma de espiral y por fragmentos a base PLGA y poli-isopreno en un modelo animal de conejos adultos blancos (11). Este estudio corrobora histológicamente los resultados obtenidos por Marques et al sobre el uso experimental de fibras de la misma mezcla de polímeros en ingeniería de tejidos (11,18). En el trabajo de Schopf et al se identifica la importancia de reducir el espesor de los stents bioabsorbibles a fin de disminuir las manifestaciones clínicas y la respuesta inflamatoria asociada a la implantación del stent (11).…”

Section: Medicinaunclassified

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Stents bronquiales bioabsorbibles y factores que afectan su velocidad de degradación

Colmenares-Roldan

Palacio

2018

CES Med

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Las causas que pueden conducir a la obstrucción de la vía aérea central pueden ser de origen funcional, por obstrucción de la luz, por lesión orgánica parietal o compresión extrínseca; a su vez, también pueden agruparse en obstrucciones malignas y no malignas. Cuando una obstrucción reduce el 50 % de la luz de la vía aérea causa síntomas debilitantes y es una de las indicaciones para implantar un stent bronquial. Los stents bronquiales actualmente disponibles son una solución incompleta para las obstrucciones de las vías aéreas. Por otra parte, un stent bronquial ideal debe cumplir con muchas características, tales como ser biocompatible, en muchos casos bioabsorbible, radio opaco, que no genere reacción inflamatoria, tener características similares a las de la vía aérea para disminuir la acumulación de secreciones, entre otras. Por esta razón los stents bronquiales bioabsorbibles se presentan como una alternativa atractiva que ofrece ciertas ventajas, aunque aún se encuentran en desarrollo. El presente artículo busca describir los avances alrededor de los stents bronquiales bioabsorbibles y los factores que afectan la degradación de los polímeros con los cuales se han fabricado.

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Section: Medicinaunclassified

Stents bronquiales bioabsorbibles y factores que afectan su velocidad de degradación

Colmenares-Roldan

Palacio

2018

CES Med

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“…This publication reports the efficacy of manufactured PLGA/PI fibres suggesting that this blend can be an attractive alternative for tissue engineering (Marques et al, 2016 ). In parallel, a study concerning about a new application of PLGA/PI as a stent was developed and the material implanted into the trachea of rabbits (Schopf et al, 2018 ). Schopf’s study demonstrated the occurrence of an inflammatory reaction in the adjacent tissue to PLGA/PI polymeric implanted fragment (Schopf et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…In parallel, a study concerning about a new application of PLGA/PI as a stent was developed and the material implanted into the trachea of rabbits (Schopf et al, 2018 ). Schopf’s study demonstrated the occurrence of an inflammatory reaction in the adjacent tissue to PLGA/PI polymeric implanted fragment (Schopf et al, 2018 ). In a recent progress, novel studies were conducted to improve and overcome limitations in the process of PLGA/PI (Cellprene®) fabrication as well as its chemical composition where modifications have been applied and new applications were tested, resulting in a new scaffold epoxidized called PLGA/PIepox (Guerra et al, 2018 ; Henckes et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Scaffold strategies combined with mesenchymal stem cells in vaginal construction: a review

et al. 2021

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Tissue engineering has provided new treatment alternatives for tissue reconstruction. Advances in the tissue engineering field have resulted in mechanical support and biological substitutes to restore, maintain or improve tissue/organs structures and functions. The application of tissue engineering technology in the vaginal reconstruction treatment can not only provide mechanical requirements, but also offer tissue repairing as an alternative to traditional approaches. In this review, we discuss recent advances in cell-based therapy in combination with scaffolds strategies that can potentially be adopted for gynaecological transplantation.

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“…Preclinical and clinical studies report using degradable biocompatible polymeric tracheal stents [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] of poly(lactic-co-glycolic acid) (PLGA), poly(L-lactic acid) (PLLA), polycaprolactone (PCL) 19 with polydioxanone ubiquitously used [8][9][10]23 for acute adult and pediatric airway obstruction treatments 8,9,22,24 . However, stent migration, repeated stenting, degradation fragment retention, and fatal dyspnea episode events are reported complications.…”

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confidence: 99%

In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction

Mady

Roy

et al. 2020

Commun Biol

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Pediatric laryngotracheal stenosis is a complex congenital or acquired airway injury that may manifest into a potentially life-threatening airway emergency condition. Depending on the severity of obstruction, treatment often requires a combination of endoscopic techniques, open surgical repair, intraluminal stenting, or tracheostomy. A balloon expandable biodegradable airway stent maintaining patency while safely degrading over time may address the complications and morbidity issues of existing treatments providing a less invasive and more effective management technique. Previous studies have focused on implementation of degradable polymeric scaffolds associated with potentially life-threatening pitfalls. The feasibility of an ultra-high ductility magnesium-alloy based biodegradable airway stents was demonstrated for the first time. The stents were highly corrosion resistant under in vitro flow environments, while safely degrading in vivo without affecting growth of the rabbit airway. The metallic matrix and degradation products were well tolerated by the airway tissue without exhibiting any noticeable local or systemic toxicity.

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Experimental use of new absorbable tracheal stent

Cited by 13 publications

References 22 publications

Stents bronquiales bioabsorbibles y factores que afectan su velocidad de degradación

Stents bronquiales bioabsorbibles y factores que afectan su velocidad de degradación

Scaffold strategies combined with mesenchymal stem cells in vaginal construction: a review

In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction

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