Active noise control (ANC) systems usually involve a large number of loudspeakers and error microphones in order to achieve noise reduction over an extended region of space. Although fundamentals of ANC theory and principles of ANC methods have been well-established over the past 40 years, applications of this technology are facing new challenges. A larger quiet zone with better noise reduction performance is always desirable in a variety of real-life scenarios. This paper presents several important factors that affect the performance of multichannel ANC systems in some popular applications such as windows with natural ventilation and quiet-zone around heads. The factors affecting acoustic design include the reflection of a baffle plate, arrangement of error sensors in open areas, and so on. In addition, different control strategies are compared and analyzed, including centralized, decentralized, and distributed strategies. All these strategies are discussed from the signal processing side, which should be considered after a proper acoustic design. One of the important aims of this paper is to provide practical guidance for acoustic design and discuss several typical control strategies for multichannel ANC systems.