A new model method for describing of the electrostatic screening in two-component systems (electron-ion plasmas, dusty plasmas, electrolytes, etc) is developed. The method is applicable to the systems of higher non-ideality degree. The expressions for all the screening parameters introduced in the previous paper (Part 1) of this work, as well as for an additional parameter characteristic for multi-component systems, are obtained. All these parameters are presented in a simple analytic form suitable for operative laboratory usage, especially for theoretical interpretation of experimental data.