Experimental Visceral Larva Migrans in the Pig

Done, J.T.; Richardson, MarionD.; Gibson, T.E.

doi:10.1016/s0034-5288(18)35015-x

Cited by 44 publications

(35 citation statements)

References 16 publications

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“…A total of 2486 (4.97%) larvae were recovered from these organs, indicating the suitability of pig tissues for migration of T. canis larvae, like many other abnormal hosts. This agrees with the previous reports of Done et al (1960), Galvin (1964), Tomimura et al (1976) and Acharya et al (2002). From the present observation it can also be concluded that T. canis larvae follow the identical migratory pattern in White Yorkshire piglets as in other paratenic hosts so far tested (Sinha, 1970; Tomimura et al , 1976; Sharma & Bhatia, 1983; Pahari & Sasmal, 1991; Acharya et al , 2002).…”

Section: Discussionsupporting

confidence: 94%

Larval migration ofToxocara canisin piglets and transfer of larvae from infected porcine tissue to mice

2008

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Visceral larva migrans (VLM), caused by Toxocara canis larvae in humans, animals and birds, is now well documented throughout the world. Seven piglets were infected orally with 5 x 104 embryonated eggs and the migration and distribution of T. canis larvae in the tissues were evaluated. After artificial gastric juice digestion, larval yields at necropsy from different organs and muscles on days 1, 3, 7, 15 and 30 post-infection (DPI) revealed 3.05, 0.97, 0.21, 0.13, 0.05, 0.14% recovery from liver, lungs, heart, kidneys, skeletal muscles and brain tissues respectively, with a total of 2486 (4.97%) recovery from all tissues together. The highest number of larvae 1527 (3.05%) was recovered from the liver throughout the period (1-30 DPI), indicating a special affinity of larvae for the liver. Subsequently five mice were each infected orally with 5 g of infected pig liver and, after necropsy on 10 DPI, 20 +/- 3.62, 17 +/- 5.10, 3 +/- 1.26, 12 +/- 3.92 and 30 +/- 5.69 larvae were recovered from liver, lungs, heart, brain and muscles, respectively. Thus, primarily, the migratory potential and adaptation of T. canis larvae in porcine tissue was examined and, subsequently, their establishment in the second paratenic host, the mouse, has been successful. No influence of host sex on the migratory potential of T. canis larvae was observed. The related pathology caused by migratory larvae and its zoonotic significance through the consumption of raw or undercooked pork has been emphasized.

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Section: Discussionsupporting

confidence: 94%

Larval migration ofToxocara canisin piglets and transfer of larvae from infected porcine tissue to mice

2008

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“…These observations coincided with macroscopic lesions on the surface of these organs, consisting of small haemorrhages and grayish-white spots. Other authors described the same lesions in response to migration of T. canis in the pig (Done et al, 1960;Helwigh et al 1999;Sommerfelt et al, 2004), in the cat (Parsons et al, 1989) and in the mice, among other species (Bisseru, 1969;Kayes and Oaks, 1978;Piergili Fioretti, et al, 1989).…”

Section: Discussionmentioning

confidence: 72%

Experimental Infection withToxocara catiin BALB/c Mice, Migratory Behaviour and Pathological Changes

Cardillo

Rosa

Ribicich

et al. 2009

Zoonoses and Public Health

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Experimental inoculations of 1000 Toxocara cati larval eggs were carried out in 18 BALB/c mice. The T. cati eggs used for inoculation were collected from the faeces of naturally infected cats. Euthanasia was performed on two mice on days 1, 2, 3, 4, 5, 6, 14, 21 and 28 post-inoculation (p.i.). Tissue samples were taken for digestion and histopathology. Larvae were recovered from all infected mice and the average of all larvae recovered was 28.3% (95%; CI: 14.1-42.4). Maximum number was obtained from liver on days 1 and 2 p.i.; from the lung on day 2 p.i. and from the brain on day 28 p.i. In muscle, the recovery was high as from day 3 p.i., with the maximum obtained on day 28 p.i. Superficial foci of congestion and haemorrhage were macroscopically observed in the lungs between days 2 and 5 p.i. and in the brain between days 3 and 6 p.i. Microscopic lesions were observed in the liver between days 2 and 14 p.i., with periportal and subcapsule inflammatory infiltrates. In the lungs, haemorrhages and inflammatory infiltrates can be observed in the alveolar parenchyma, close to bronchioles and large blood vessels. In the brain, congestive areas without inflammatory reactions were seen. In muscle, the presence of inflammatory infiltrates and degenerated muscle can be observed surrounding a parasite larva. These same lesions were observed in myocardium and pericardium. The kidneys were congested with inflammatory infiltrates. The inflammatory cells present in all the tissues studied were lymphocytes, neutrophils and a few eosinophils. Formation of granulomas or signs of larva encapsulation were not observed. The migratory pattern of T. cati larvae in BALB/c mice and its tendency to become concentrated in the muscle reinforce the importance of the mouse as a paratenic host for the parasite's cycle in the environment.

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“…Besides the knovvn placental animals, the possum can serve as a reservoir of 1'. canis and the larval distribution in this host appears to be more like that in swine (Done, et at., 1960) and sheep (Sweatman, ct at.) 1962) than in mice (Sprent, 1952;1953).…”

Section: Discussionmentioning

confidence: 98%

The potential role of the possum(Trichosurus vulpecula)as a transport host ofToxocara canis

Sweatman

1962

New Zealand Veterinary Journal

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Experimental Visceral Larva Migrans in the Pig

Cited by 44 publications

References 16 publications

Larval migration ofToxocara canisin piglets and transfer of larvae from infected porcine tissue to mice

Larval migration ofToxocara canisin piglets and transfer of larvae from infected porcine tissue to mice

Experimental Infection withToxocara catiin BALB/c Mice, Migratory Behaviour and Pathological Changes

The potential role of the possum(Trichosurus vulpecula)as a transport host ofToxocara canis

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