Experimental Yersinia enterocolitica placentitis in sheep

Corbel, M.J.; Ellis, B; Richardson, Carol; Bradley, R.

doi:10.1016/0007-1935(92)90086-g

Cited by 18 publications

(27 citation statements)

References 19 publications

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“…Similar findings were reported by Robins‐Browne et al [68] who found that gnotobiotic piglets, inoculated perorally with a biotype 1A strain of serotype O:5, which was originally isolated from milk, rapidly cleared the bacteria without developing any clinical or pathological evidence of disease. Interestingly, however, Corbel et al [69] reported that a biotype 1A strain (serotype O:6) which was isolated from the liver of an aborted lamb, caused placentitis and abortion when inoculated into pregnant ewes. This finding suggests that animals may differ in their susceptibility to infection with biotype 1A yersiniae or that the pathogenicity of different biotype 1A strains may vary.…”

Section: Evidence Favouring the Lack Of Virulence Of Biotype 1a Strainsmentioning

confidence: 99%

Pathogenicity ofYersinia enterocoliticabiotype 1A

Tennant

Grant

Robins-Browne

2003

FEMS Immunology &Amp; Medical Microbiology

132

114

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Yersinia enterocolitica strains of biotype 1A lack the known virulence determinants of strains in other categories, including the Yersinia virulence plasmid (pYV), and several chromosomal markers of pathogenicity. For this reason, and also because Y. enterocolitica strains of biotype 1A are frequently isolated from the environment or asymptomatic individuals, these bacteria are often assumed to be avirulent. On the other hand, there is a considerable body of clinical, epidemiological and experimental evidence to indicate that at least some strains of Y. enterocolitica biotype 1A are able to cause gastrointestinal symptoms which resemble those caused by pYV-bearing strains. The availability of a number of experimental systems, including cell culture and animal models of infection, provides an opportunity to identify and characterise the essential virulence determinants of biotype 1A strains.

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Section: Evidence Favouring the Lack Of Virulence Of Biotype 1a Strainsmentioning

confidence: 99%

Pathogenicity ofYersinia enterocoliticabiotype 1A

Tennant

Grant

Robins-Browne

2003

FEMS Immunology &Amp; Medical Microbiology

132

114

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“…Y. enterocolitica biovar 1A has also been implicated in nosocomial [8] and food-borne [9] outbreaks. A serotype O:6,30 (biovar 1A) strain was reported to cause placentitis and abortion in pregnant ewes [10]. Y. enterocolitica biovar 1A was the most predominant biovar isolated from both livestock and humans during a survey in Great Britain in 1999-2000 and surely needs to be studied further [11].…”

Section: Introductionmentioning

confidence: 99%

Genetic relationships between clinical and non-clinical strains of Yersinia enterocolitica biovar 1A as revealed by multilocus enzyme electrophoresis and multilocus restriction typing

Mallik

Virdi

2010

BMC Microbiology

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BackgroundGenetic relationships among 81 strains of Y. enterocolitica biovar 1A isolated from clinical and non-clinical sources were discerned by multilocus enzyme electrophoresis (MLEE) and multilocus restriction typing (MLRT) using six loci each. Such studies may reveal associations between the genotypes of the strains and their sources of isolation.ResultsAll loci were polymorphic and generated 62 electrophoretic types (ETs) and 12 restriction types (RTs). The mean genetic diversity (H) of the strains by MLEE and MLRT was 0.566 and 0.441 respectively. MLEE (DI = 0.98) was more discriminatory and clustered Y. enterocolitica biovar 1A strains into four groups, while MLRT (DI = 0.77) identified two distinct groups. BURST (Based Upon Related Sequence Types) analysis of the MLRT data suggested aquatic serotype O:6,30-6,31 isolates to be the ancestral strains from which, clinical O:6,30-6,31 strains might have originated by host adaptation and genetic change.ConclusionMLEE revealed greater genetic diversity among strains of Y. enterocolitica biovar 1A and clustered strains in four groups, while MLRT grouped the strains into two groups. BURST analysis of MLRT data nevertheless provided newer insights into the probable evolution of clinical strains from aquatic strains.

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“…127 In a Nebraska flock outbreak, Y. pseudotuberculosis caused suppurative placentitis and abortion in ewes from 75 days of gestation, death of term lambs, and death of the ewe in several cases. 129 129 …”

Section: Yersinia Spp (Yersiniosis)mentioning

confidence: 99%

Theriogenology of Sheep and Goats

Edmondson,

Roberts,

Baird

et al. 2012

Sheep and Goat Medicine

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Experimental Yersinia enterocolitica placentitis in sheep

Cited by 18 publications

References 19 publications

Pathogenicity ofYersinia enterocoliticabiotype 1A

Pathogenicity ofYersinia enterocoliticabiotype 1A

Genetic relationships between clinical and non-clinical strains of Yersinia enterocolitica biovar 1A as revealed by multilocus enzyme electrophoresis and multilocus restriction typing

Theriogenology of Sheep and Goats

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