Experimentally Confirmed Induction of Sweet’s Syndrome by Phototesting

Meyer,; Sw, Schneider; Bonsmann, Giesela; Beissert, Stefan

doi:10.2340/00015555-1139

Cited by 14 publications

(5 citation statements)

References 9 publications

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“…SS may also result from a hypersensitivity reaction to a bacterial or viral antigen [ 16 ]. It has been postulated that photosensitivity may also play a role in the pathogenesis of SS, although the mechanism is unknown [ 17 ]. Furthermore, an alteration in the gene encoding protein tyrosine phosphatase nonreceptor 6 appears to be involved in the pathogenesis of SS and other subsets of neutrophilic dermatoses [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Histiocytoid Sweet’s syndrome in a patient with myelodysplastic syndrome: report and review of the literature

Shalaby

Riahi

Rosen

et al. 2016

Dermatol Pract Concept

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The neutrophilic dermatoses are a group of disorders characterized by skin lesions for which histological examination reveals intense epidermal and/or dermal inflammatory infiltrates composed primarily of neutrophils without evidence of infection. The myelodysplastic syndromes consist of a heterogeneous group of malignant hematopoietic stem cell disorders characterized by dysplastic and inadequate blood cell production with a variable risk of transformation to acute leukemia. Rarely, histiocytoid Sweet’s syndrome occurring in patients with myelodysplastic syndrome has been described. We present a case of a 66-year-old woman with a history of myelodysplastic syndrome who developed histiocytoid Sweet’s syndrome. We also review the literature and characterize patients with myelodysplastic syndrome who have developed histiocytoid Sweet’s syndrome.

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Section: Discussionmentioning

confidence: 99%

Histiocytoid Sweet’s syndrome in a patient with myelodysplastic syndrome: report and review of the literature

Shalaby

Riahi

Rosen

et al. 2016

Dermatol Pract Concept

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“…Histopathological diagnostic criteria for N-SS involve a diffuse neutrophilic infiltrate of the dermis, edema and presence of neutrophils, as predominant cells in the infiltrate, some with nuclear fragmentation [ 54 , 55 ]. Other cells’ presence has been observed, such as eosinophils, on skin biopsies in classical or drug-induced variants of the syndrome [ 13 ] or lymphocytes or histiocytes in rare cases [ 50 , 56 ]. The presence of a perivascular neutrophilic infiltrate may lead to leukocytoclastic vasculitis [ 15 , 57 ], a characteristic aspect of postcapillary venules.…”

Section: Resultsmentioning

confidence: 99%

“…It has also been hypothesized that photosensitivity may play a role in Sweet syndrome. Although the exact pathological mechanism is unknown, the syndrome has been experimentally induced by phototesting [ 56 ]. One theory suggests that an isomorphic Koebner reaction is involved; another proposed mechanism associates ultraviolet B radiation with neutrophil activation and epidermal production of tumor necrosis factor-alpha and interleukin 8 [ 66 , 67 , 68 , 69 ].…”

Section: Resultsmentioning

confidence: 99%

Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

Ferea

Mihai

Bălan

et al. 2023

Life

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Sweet syndrome (SS) is a rare disease described as a febrile neutrophilic dermatosis with acute onset, the pathogenesis of which has not yet been elucidated. The syndrome is characterized by the sudden onset of erythematous infiltrated papules or plaques located on the upper body and is associated with fever, leukocytosis and neutrophilia. The lesions show a dense dermal infiltration with mature neutrophils. The condition is responsive to systemic steroids. The central nervous system, bones, muscles, eyes, ears, mouth, heart, lung, liver, kidneys, intestines, and spleen may be affected by SS as extracutaneous manifestations. More and more cases have been found to be associated with malignancies, particularly myelodysplastic syndrome, and, less frequently, other hematologic malignancies or solid tumors. Approximately 21% of patients with SS have an associated malignancy and up to 80% of MASS cases are associated with hematological diseases, predominantly myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Myelodysplastic syndrome is a clonal disease of the bone marrow characterized by inefficient hematopoiesis, dysplasia of the bone marrow and peripheral cytopenias. Affected patients have a high risk of leukemic transformation. After analyzing later studies and current practical aspects regarding MDS-related SS, we suggest an algorithm for evaluating these patients.

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“…Les patients ayant reçu une radiothérapie peuvent présenter des lésions de syndrome de Sweet aux sites irradiés, de même que lors d'une photo-exposition (figure 4). 13,14 Des lésions extracutanées peuvent toucher quasiment tous les organes (poumons, reins, intestins, foie, coeur, muscles, rate, os, oreilles et système nerveux central).…”

Section: Présentation Cliniqueunclassified

Syndrome de Sweet : un diagnostic à ne pas manquer

Lang¹,

Quenan²

2017

Revue Médicale Suisse

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Le syndrome de Sweet est une dermatose neutrophilique rare. Les patients présentent classiquement une apparition brutale de lésions cutanées douloureuses sous forme de papules, nodules ou plaques érythémateuses asymétriques localisées préférentiellement sur les extrémités supérieures, le visage et le cou, associées à une fièvre élevée, une neutrophilie et, à l'histologie, un infiltrat diffus de neutrophiles dans le derme. Le plus souvent idiopathique, il peut être en lien avec des infections respiratoires et gastro-intestinales, avec des maladies inflammatoires de l'intestin, avec une grossesse ou une vaccination. Des formes médicamenteuses et paranéoplasiques ont été rapportées. A l'aide d'images cliniques et de deux cas cliniques, nous souhaitons rappeler les points essentiels nécessaires au diagnostic et à la prise en charge de cette maladie. Sweet's syndrome, a diagnosis to keep in mindSweet's syndrome is a rare neutrophilic dermatosis. Typically, patients present with a sudden onset of tender erythematous skin lesions (papules, nodules, and plaques), of asymetrical distribution, located preferentially on the superior limbs, face and neck, associated whith high fever and neutrophilia. Histologicaly, there is a diffuse infiltrate of neutrophils located in the dermis. Most of the time idiopathic, it may be associated with a respiratory or gastrointestinal infection, with inflammatory bowel disease, pregnancy and vaccination. A drug-induced form and a malignancy-associated form have been described. Based on illustrations and two clinical cases, we wish to focus on the diagnostic strategy and the management of this disease.

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Experimentally Confirmed Induction of Sweet’s Syndrome by Phototesting

Cited by 14 publications

References 9 publications

Histiocytoid Sweet’s syndrome in a patient with myelodysplastic syndrome: report and review of the literature

Histiocytoid Sweet’s syndrome in a patient with myelodysplastic syndrome: report and review of the literature

Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

Syndrome de Sweet : un diagnostic à ne pas manquer

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