Experimentally Induced Burns in Rats Treated with Innovative Polymeric Films Type Therapies

Grosu, Oxana-Mădălina; Dragostin, Oana-Maria; Gardikiotis, Ioannis; Chiţescu, Carmen Lidia; Lisa, Elena Lacramioara; Zamfir, Alexandra-Simona; Confederat, Luminiţa; Dragostin, Ionuţ; Stan, Cristinel Ionel; Zamfir, C.

doi:10.3390/biomedicines11030852

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…As a useful wound dressing, the first and foremost thing is its antibacterial performance [ 63 , 64 , 65 ]. Bacterial counts and antibacterial rates in the culture medium were determined using the plate counting method at 6, 12, and 24 h of incubation.…”

Section: Resultsmentioning

confidence: 99%

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

Zhou,

Wang,

Gong

et al. 2023

Biomedicines

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In this nanotechnology era, nanostructures play a crucial role in the investigation of novel functional nanomaterials. Complex nanostructures and their corresponding fabrication techniques provide powerful tools for the development of high-performance functional materials. In this study, advanced micro-nanomanufacturing technologies and composite micro-nanostructures were applied to the development of a new type of pharmaceutical formulation, aiming to achieve rapid hemostasis, pain relief, and antimicrobial properties. Briefly, an approach combining a electrohydrodynamic atomization (EHDA) technique and reversed-phase solvent was employed to fabricate a novel beaded nanofiber structure (BNS), consisting of micrometer-sized particles distributed on a nanoscale fiber matrix. Firstly, Zein-loaded Yunnan Baiyao (YB) particles were prepared using the solution electrospraying process. Subsequently, these particles were suspended in a co-solvent solution containing ciprofloxacin (CIP) and hydrophilic polymer polyvinylpyrrolidone (PVP) and electrospun into hybrid structural microfibers using a handheld electrospinning device, forming the EHDA product E3. The fiber-beaded composite morphology of E3 was confirmed through scanning electron microscopy (SEM) images. Fourier-transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis revealed the amorphous state of CIP in the BNS membrane due to the good compatibility between CIP and PVP. The rapid dissolution experiment revealed that E3 exhibits fast disintegration properties and promotes the dissolution of CIP. Moreover, in vitro drug release study demonstrated the complete release of CIP within 1 min. Antibacterial assays showed a significant reduction in the number of adhered bacteria on the BNS, indicating excellent antibacterial performance. Compared with the traditional YB powders consisting of Chinese herbs, the BNS showed a series of advantages for potential wound dressing. These advantages include an improved antibacterial effect, a sustained release of active ingredients from YB, and a convenient wound covering application, which were resulted from the integration of Chinese herbs and Western medicine. This study provides valuable insights for the development of novel multiscale functional micro-/nano-composite materials and pioneers the developments of new types of medicines from the combination of herbal medicines and Western medicines.

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Section: Resultsmentioning

confidence: 99%

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

Zhou,

Wang,

Gong

et al. 2023

Biomedicines

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Second‐degree burns treatment: Preclinical in vivo approaches using natural latex rubber containing Aloe vera extract

de Carvalho,

Quevedo,

Goldenberg

et al. 2024

J of Applied Polymer Sci

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Natural rubber latex (NRL) obtained from Hevea brasiliensis is emerging as a viable and economical alternative for biomedical treatments, particularly for dermal injuries. Its effectiveness is enhanced when combined with bioactive molecules, such as those found in Aloe vera (AV), known for their healing properties and are commonly used in low‐cost wound healing therapies. Thus, this study evaluated the physicochemical and biological properties of NRL incorporated with 25%, 35%, and 50% AV, both in vitro and in vivo. FTIR analyses revealed only physical interactions between NRL and AV, facilitating their release, as evidenced by the release profile. In vitro assays indicated improved biocompatibility in samples composed of 25% and 35% AV, while complete cell death occurred at 50% AV. Histological evaluations of second‐degree burn models in rats showed greater re‐epithelialization of the epidermis with 35% AV after 14 days of treatment. However, 50% AV highlighted the importance of avoiding overdosing to prevent tissue necrosis. Despite the differences observed between in vitro and in vivo results, NRL membranes containing AV are a promising approach for future clinical trials in skin wounds treatment, offering an effective and affordable solutions for skin regeneration in clinical settings.

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Ointment Formulation of Tapak Dara (Catharanthus roseus (L.) G. Don) Flower Ethanol Extract and its Activity in Burn-Healing

Leny,

Situmorang,

Siagian

et al. 2023

Borneo J Pharm

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Treatment done on burn wounds is intended to provide local therapy to heal as quickly as possible. The content of secondary metabolites in the tapak dara (Catharanthus roseus (L.) G. Don) flower can help the healing process of burns, namely alkaloids, saponins, tannins, and flavonoids. Alkaloids act as antibacterial; saponins can trigger collagen formation; tannins as astringents that cause shrinkage of skin pores and stop minor bleeding in wounds; and flavonoids have anti-inflammatory effects. This study aimed to formulate an ointment of C. roseus flower ethanol extract and determine its physical characteristics such as organoleptic test, homogeneity, pH value, dispersion, and stability test of the preparation and examine the activity as a burn healer in white male rats. The research data were analyzed statistically using the ANOVA method, followed by the LSD test (least significant difference) to see how the ointment-containing extract reduced the diameter and percentage of the burn wounds. The results show that all ethanol extracts of C. roseus flower ointments met the requirements for its physical characteristic tests. It offers a good activity as a burn healer in white male rats. The most effective concentration is an ointment containing 15% of ethanol extract from C. roseus flower (F3 group), which shows a significant difference (p <0.05) from the blank and the other group formula in burn wound healing.

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Experimentally Induced Burns in Rats Treated with Innovative Polymeric Films Type Therapies

Cited by 3 publications

References 38 publications

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

Integrating Chinese Herbs and Western Medicine for New Wound Dressings through Handheld Electrospinning

Second‐degree burns treatment: Preclinical in vivo approaches using natural latex rubber containing Aloe vera extract

Ointment Formulation of Tapak Dara (Catharanthus roseus (L.) G. Don) Flower Ethanol Extract and its Activity in Burn-Healing

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