Experimentally induced spine osteoarthritis in rats leads to neurogenic inflammation within neurosegmentally linked myotomes

Duarte, Felipe C. K.; Hurtig, Mark; Clark, Arthur W.; Brown, Stephen H.M.; Simpson, Jeremy A.; Srbely, John

doi:10.1016/j.exger.2021.111311

Cited by 5 publications

(14 citation statements)

References 63 publications

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“… 42 One of the primary stimuli of muscle pain is neurogenic inflammation resulting from lumbar facet joint osteoarthritis. 5 Since the nerves that transmit information to and from the lower/hind limbs originate in the lower back and so any pressure on a spinal column nerve roots can cause back pain as well as trigger neurological inflammation in the neurosegmentally linked muscles. 5 Treatment’s goal is to eliminate inflammation, restore muscle performance, reduce morbidity, and improve quality of life.…”

Section: Discussionmentioning

confidence: 99%

“… 5 Since the nerves that transmit information to and from the lower/hind limbs originate in the lower back and so any pressure on a spinal column nerve roots can cause back pain as well as trigger neurological inflammation in the neurosegmentally linked muscles. 5 Treatment’s goal is to eliminate inflammation, restore muscle performance, reduce morbidity, and improve quality of life. Tailoring the treatment of facet pain to the intensity of neurogenic inflammation could aid in optimizing its efficiency.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies also revealed that certain neurogenically mediated pro-inflammatory peptides such as substance P and protease-activated receptor 2 (PAR2) accumulated in the neurosegmentally linked myotome following facet injury. 5 These regulators of inflammation initiate the cascade of processes including perivascular, epimysial, perimysial, and endomysial infiltration of immune cells with accompanying edema in the acute phase, and generation of residual inflammatory by-products or fibrosis in the subacute or chronic stage of inflammation. 4 , 6 Accumulation of inflammatory mediators in skeletal muscles may lead to considerable changes in their microstructure and chemical composition.…”

Section: Introductionmentioning

confidence: 99%

“…Neurogenic inflammation is commonly associated with somatosensory changes that are detectable using quantitative sensory testing techniques assessing mechanical pain threshold and allodynia. 4 , 5 The electronic von Frey test and heat stimuli 19 are commonly used to evaluate pain response in both humans and animals. Punctate mechanical allodynia and hyperalgesia can be measured using a pinprick or monofilaments of varying forces applied to affected dermatomes (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasonographic assessment of skeletal muscles after experimentally induced neurogenic inflammation (facet injury) in rats

Ahmadi¹,

Issa²,

Duarte

et al. 2022

Exp Biol Med (Maywood)

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This study set out to examine ultrasonographic attributes of non-neurosegmentally (pectoral-forelimb) and neurosegmentally linked (hindlimb) myotomes in an experimental model that leads to neurogenic inflammation in segmentally linked myotomes, and to evaluate quantitative correlations among ultrasonographic attributes of the muscles, relative content of various inflammatory mediators, and nociceptive thresholds (hot and mechanical) in rats. Twelve male Wistar Kyoto rats were randomly divided into two equinumerous groups: surgery group, in which the left lumbar (L4–L6) facet joints were compressed for 3 min with modified Kelly forceps under general anesthesia, and sham-operated rats. All ultrasonograms were obtained with the Vevo 2100 Visual Sonic scanner connected to a 24-MHz transducer at four different time points: pre-surgery and 7, 14, and 21 days after surgical procedures. Digital ultrasonographic images of quadriceps femoris, hamstring, and pectoral-brachial muscle groups were analyzed using a polygonal meter region of interest placed on the largest cross-sectional area of the muscles displayed in Image ProPlus® analytical software to compute numerical pixel values and pixel heterogeneity (standard deviation of mean pixel values). On day 21, pain behavior tests (hot plate and von Frey) were performed and then all animals were euthanized. Protein expression of inflammatory mediators in biceps brachii and rectus femoris muscles was measured by Western blot. The most prominent differences in muscle echotextural attributes between the two subsets of rats occurred 14 days post-surgery in pectoral-brachial and quadriceps femoris muscles. The expression of calcitonin-gene-related peptide was directly related to both echotextural variables only in biceps brachii (pixel intensity: r = 0.65, P = 0.02; and heterogeneity: r = 0.66, P = 0.02, respectively). Our findings have revealed the occurrence of echotextural changes in skeletal muscles of rats during myositis; however, the accumulation of inflammatory mediators and the outcomes of sensory tests did not relate to the changes in first-order echotextural characteristics of affected hindlimb muscles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ultrasonographic assessment of skeletal muscles after experimentally induced neurogenic inflammation (facet injury) in rats

Ahmadi¹,

Issa²,

Duarte

et al. 2022

Exp Biol Med (Maywood)

Self Cite

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“…3,15,16,69,78 Interestingly, it has been hypothesized that neurogenic inflammation may subsidize the nociceptive and biomolecular changes underlining the pathophysiology of each condition (OA and MPS) and likely their coexistence (MPS and MTrPs with OA). 77,81,82 For example, a persistent nociceptive input to small diameter afferents at the OA joint may lead to increased neuronal firing, persistent nociception, and segmental sensitization in the CNS. 81,82 This may incite an antidromic reflex neurogenic inflammation and the release of neurogenic substances (eg, substance P, calcitonin gene-related peptide) toward the peripherally neurologically supplied skeletal muscle and joint tissues by the common spinal sensitized segment.…”

Section: Hypothetical Mechanisms Underlying the Mps Coexistence With Oamentioning

confidence: 99%

Myofascial Pain as an Unseen Comorbidity in Osteoarthritis

Duarte

Chien

Ghazinour

et al. 2023

The Clinical Journal of Pain

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Objective: This review aimed to identify, summarize, and appraise the evidence supporting the coexistence of myofascial pain (MPS) and trigger points (MTrP) in osteoarthritis (OA), and the effectiveness of MTrPs treatments in OA-related pain and physical function outcomes. Methods: Three databases were searched from inception to June 2022. We included observational and experimental studies to fulfill our 2 study aims. Two independent reviewers conducted 2-phase screening procedures and risk of bias using checklist tools for cross-sectional, quasi-experimental, and randomized control trials. Patient characteristics, findings of active and latent MTrPs in relevant muscles, treatments, and pain and physical function outcomes were extracted from low-risk bias studies. Results: The literature search yielded 2898 articles, of which 6 observational and 7 experimental studies had a low bias risk and the data extracted. Active MTrPs in knee OA patients was more evident in the quadriceps and hamstring muscles than in healthy individuals. Dry needling on active MTrPs improved pain and physical function in the short term compared with sham treatment in hip OA patients. In knee OA, dry needling on latent or active MTrPs improved pain and functional outcomes compared with sham needling but did not result in better pain and physical outcomes when combined with a physical exercise program. Discussion: The presence of active versus latent MTrPs seems to be a more sensitive discriminating feature of OA given that latent is often present in OA and healthy individuals. Dry needling on active MTrPs improved pain and physical function in the short term compared with sham treatment in hip OA patients. However, the small sample size and the few number of studies limit any firm recommendation on the treatment. Registry: The study protocol was prospectively registered in Open Science Framework (https://doi.org/10.17605/OSF.IO/8DVU3).

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Rehmannia alcohol extract inhibits neuropeptide secretion and alleviates osteoarthritis pain through cartilage protection

Huang,

Lin,

Tan

et al. 2023

Heliyon

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Experimentally induced spine osteoarthritis in rats leads to neurogenic inflammation within neurosegmentally linked myotomes

Cited by 5 publications

References 63 publications

Ultrasonographic assessment of skeletal muscles after experimentally induced neurogenic inflammation (facet injury) in rats

Ultrasonographic assessment of skeletal muscles after experimentally induced neurogenic inflammation (facet injury) in rats

Myofascial Pain as an Unseen Comorbidity in Osteoarthritis

Rehmannia alcohol extract inhibits neuropeptide secretion and alleviates osteoarthritis pain through cartilage protection

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