Experimentally Produced Zinc Deficiency in the Goat

Miller, W.J.; Pitts, William J.; Clifton, C.M.; Schmittle, S. C.

doi:10.3168/jds.s0022-0302(64)88713-0

Cited by 57 publications

(19 citation statements)

References 6 publications

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“…Zinc deficiency in rats, piglets and young ruminants results in depressed food intake, decreased rate of gain in liveweight and a reduced efficiency of food utilization (Follis et al 1941;Miller 1960, 1962;Miller et al 1964;Ott et al 1964Ott et al , 1965Mills et al 1967;Somers and Underwood 1969;Underwood and Somers 1969).…”

Section: Introductionmentioning

confidence: 99%

“…Accompanying clinical symptoms which develop in calves, lambs, kids and piglets include dermatitis, parakeratotic scabby lesions and alopecia around the eyes and mouth and on the nose, ears, neck, ventral areas, scrotum and legs (Tucker and Salmon 1955;Leucke et al 1956;Miller 1960, 1962;Miller et al 1964;Ott et al 1964Ott et al , 1965Mills et al 1967;Underwood and Somers 1969). In extreme cases the parakeratosis in piglets (Lewis et al 1956) and the alopecia in calves (Ott et al 1965) and lambs may involve all body regions.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Zinc Deficiency on the Wool Growth, Skin and Wool Follicles of Pre-ruminant Lambs

Masters¹,

Chapman²,

Vaughan³

1985

Aust. Jnl. Of Bio. Sci.

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Two groups of I-month-old pre-ruminant lambs of similar mean liveweights were fed identical liquid milkreplacer diets except that the zinc contents were either 5 p.g (deficient diet) or 32 p.g per gram of dry matter (control diet). These diets were fed for 4 weeks, after which all the lambs received the control diet for 2 weeks.In the lambs fed the deficient diet plasma zinc concentration decreased markedly during the first 2 weeks and skin lesions developed around their mouths. Autophagic vacuoles also developed in most follicle bulbs along with a variety of defects in the wool fibres and progressive inhibition of wool growth. Food intake and liveweight increase were not significantly depressed until the third and fourth weeks of feeding the deficient diet. During this period the wool was shed from the zinc-deficient lambs as a result of the fibres being degraded and distorted within thickened outer root sheaths in the distal (upper) parts of the follicles. In addition, the epidermis of the wool-bearing skin became slightly acanthotic and hyperkeratotic, although not parakeratotic.When the deficient lambs were fed the control diet for 2 weeks, their food intake, liveweight gain and plasma zinc concentration increased to almost those of the control lambs, but their rate of wool growth was still low and the epidermis had not returned to normal. Compared with previous studies the findings of this study suggest that pre-ruminant lambs may be more susceptible to the effects of zinc deficiency than ruminant lambs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Zinc Deficiency on the Wool Growth, Skin and Wool Follicles of Pre-ruminant Lambs

Masters¹,

Chapman²,

Vaughan³

1985

Aust. Jnl. Of Bio. Sci.

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“…Some LP animals developed ascites which resulted in the potbellied appearance typical of human kwashiorkor [26]. Growth failure is a common manifestation of zinc deficiency in many species and has been related to decreased food intake secondary to impaired taste acuity [21 ]. Growth failure is a common manifestation of zinc deficiency in many species and has been related to decreased food intake secondary to impaired taste acuity [21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Guinea pigs maintained on LZ diet did not grow normally despite their diet being adequate in all other known nutrients [22]. Alopecia has been documented in experimental zinc deficiency in other species [21 ]. Other characteristics of zinc deficiency observed in LZ animals included patchy alopecia over the caudal back, rump, and extremities.…”

Section: Discussionmentioning

confidence: 99%

Effect of protein and zinc deficiencies on vaccine efficacy in guinea pigs following pulmonary infection with Listeria

Coghlan

Carlomagno

McMurray

1988

Med Microbiol Immunol

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Specific pathogen-free guinea pigs were maintained for 3 weeks on purified diets containing 30% protein (ovalbumin) and 50 ppm added zinc (Control-C), 10% protein and 50 ppm added zinc (low protein-LP), or 30% protein and no added zinc (low zinc-LZ). Half of the animals in each diet group were vaccinated intraperitoneally with 2.5 x 10(3) viable Listeria monocytogenes organisms after 8 days of diet treatment. Ten days later, all animals received an aerosol challenge of 250 L. monocytogenes organisms and were killed 4 days later. Both zinc and protein deficiency resulted in animals that were growth retarded as compared to controls. Specific nutrient effects were observed as significant reductions in total serum proteins (LP group) and plasma zinc concentrations (LZ group). In vaccinated guinea pigs, both protein and zinc deprivation resulted in significant impairment of delayed-type hypersensitivity (DTH) responses following the intradermal injection of listeria antigen. Diet did not exert a measurable impact on the response of nonvaccinated guinea pigs to pulmonary listeriosis. Prior vaccination allowed both malnourished groups to control the challenge infection successfully as measured by significant reductions in viable bacilli recovered from the lung, spleen and hilar lymph nodes. The diet and vaccine effect varied depending on the tissue examined. Thus, although both protein and zinc deficiencies resulted in loss of peripheral antigen-specific T lymphocyte function (DTH), vaccine efficacy was not impaired.

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“…In the testes of laboratory and domestic animals, zinc deficiency has been known to inhibit testicular development (FOLLIs et al, 1941;MILLAR et al, 1958, MILLER et al, 1964PITTS et a1., 1966;PRASAD et al, 1967), cause abnormal spermiogenesis (ORGEBIN-CRIST et al, 1971;DINSDALE and WILLIAMS, 1980), affect Leydig cell functions and the pituitary-gonadal axis (LEI et al, 1976;HESKETH, 1982), and decrease the calmodulin content of the testes (LAW et al, 1987). Notwithstanding these various studies, no zinc deficiency experiments seem to have been performed with regard to the protein secretory functions of the testis.…”

mentioning

confidence: 99%

Effects of Dietary Zinc Deficiency on Protein Secretory Functions of the Mouse Testis.

Ueda

Kayama

Mori

et al. 1991

Archives of Histology and Cytology

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Experimentally Produced Zinc Deficiency in the Goat

Cited by 57 publications

References 6 publications

Effects of Zinc Deficiency on the Wool Growth, Skin and Wool Follicles of Pre-ruminant Lambs

Effects of Zinc Deficiency on the Wool Growth, Skin and Wool Follicles of Pre-ruminant Lambs

Effect of protein and zinc deficiencies on vaccine efficacy in guinea pigs following pulmonary infection with Listeria

Effects of Dietary Zinc Deficiency on Protein Secretory Functions of the Mouse Testis.

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