Experimentelle Erzeugung von Tumoren des Nervensystems

Mennel, H. D.; Ivanković, S.

doi:10.1007/978-3-642-80888-3_2

Cited by 10 publications

(1 citation statement)

References 130 publications

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“…Tumors have been induced by transplacental, systemic or local application of chemical carcinogens, by transplantation, by intracarotid or intracerebral injection of suspended neoplastic cells. Examples are the ethylnitrosourea-induced oligodendroglioma or mixed glioma [1], avian sarcoma virus induced anaplastic or polymorphic astrocytoma [2], metastatic Walker-255 carcinoma [3], or the implantation of cloned tumor cells such as RG1 2.2 [4] or RT9 glioma [5]. For the present study we chose the RG1 2.2 glioma because intracerebral growth of this tumor exhibits a high degree of reproducibility after stereotaxic inoculation.…”

Section: Introductionmentioning

confidence: 99%

Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG12.2) of rat brain

Mies¹,

Paschen²,

Ebhardt³

et al. 1990

J Neuro-Oncol

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In experimental RG1 2.2 glioma of rat brain, local blood flow, glucose utilization, protein synthesis, glucose and ATP content were measured by means of triple tracer autoradiography and bioluminescence technique, respectively, to determine hemodynamic and metabolic thresholds for local tumor energy failure. Perfusion thresholds were estimated at tumor blood flow values of 69.0 +/- 0.1 ml/100 g/min (estimate +/- standard error) and of 69 +/- 7.1 ml/100 g/min for the beginning of the decline in regional ATP and glucose content, respectively. Metabolic thresholds were derived at tumor glucose utilization values of 70.6 +/- 8.3 mumol/100 g/min for reduced protein synthesis, of 55.0 +/- 0.2 mumol/100 g/min for the decrease in glucose content, and 34.7 +/- 4.7 mumol/100 g/min for decline in ATP content. Our results suggest that blood flow limits glucose supply to tumor tissue at much higher flow rates than in normal brain which, in turn, is associated with a decrease in tumor glucose utilization. A reduction and not an increase in tumor glucose availability could be a more appropriate strategy for the induction of energy failure in tumors.

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Section: Introductionmentioning

confidence: 99%

Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG12.2) of rat brain

Mies¹,

Paschen²,

Ebhardt³

et al. 1990

J Neuro-Oncol

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Neurotropic Carcinogenesis

Zeller¹

1994

Selective Neurotoxicity

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Hepatocarcinogenetic effect of DENA in pigs

Graw

Berg

1977

Z. Krebsforsch.

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DENA was fed to Göttingen mini-pigs at a dose of 0.4 mg/kg body weight with a total dosage of 420 mg/kg over an experimental period of five years. The animals showed multiple neoplasia of the liver with all transitions, including hepatocellular carcinoma and Kupffer-cell sarcoma with metastases in the regional lymph nodes and the lung. Two animals had metastases in the lung as well as one renal carcinoma and one tumor in the hemisphere of the brain.

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Experimentelle Erzeugung von Tumoren des Nervensystems

Cited by 10 publications

References 130 publications

Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG12.2) of rat brain

Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG12.2) of rat brain

Neurotropic Carcinogenesis

Hepatocarcinogenetic effect of DENA in pigs

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