Experimentelle Untersuchungen über Asthma bronchale¹

Back to the future: re-establishing guinea pigin vivoasthma models

“…Likewise, airway remodeling may be induced in guinea pigs. Already in the 1930s it was observed that repeated antigen challenges of guinea pigs over several weeks induced structural changes in the airways, including goblet cell hyperplasia and increased ASM mass ( [34], discussed in [35]), observations that have been confirmed and extended in more recent studies [32,[36][37][38][39][40].…”

Evaluation of Bronchoprotective Effect of Ferula Asafetida in Guinea pigs

“…[17,18] Guineapigs were exposed to 0.5% w/v of histamine di-hydrochloride aerosol blown into the chamber through the nebulizer under 300mm Hg pressure.The end point pre convulsive dyspnea (PCD) was determined from the time of aerosol exposure to the onset of dyspnea leading to the appearance of convulsion. Any animal without pretreatment of drugs, if does not develop the typical features of asphyxia for more than three minutes, the animal was considered as resistant and such animals were excluded from the experiment.…”

Insight into Pulmonary Gas Trapping as an Index of Airway Responses in Small Laboratory Animals

“…Further they noted the nearly fully distended lungs floated on water. Twenty-seven years later, Kallos and Pagel [5] found marked distension of lungs from guinea pigs that died during either inhaled antigen or histamine challenge. Examples of normal versus hyperinflated guinea-pig lungs are shown in Figure 2.…”