“…Histopatbological studies of spontaneous setae-induced lesions arc very scanty, but the pathological events in lesions produced experimentally (Tyzzer, 1970;Pawlowsky & Stein, 1927;Ishizaki & Nagai, 1958;de Jong et al, 1976) arc likely to be similar. In tbe early stages there is focal disruption ofthe stratum corneum with associated localised lysis of epidermal cells giving rise to an intraepidermai vesicle.…”