When a fast-moving drop impacts onto a smooth substrate, splashing will be produced at the edge of the expanding liquid sheet. This ubiquitous phenomenon lacks a fundamental understanding. Combining experiment with model, we illustrate that the ultrathin air film trapped under the expanding liquid front triggers splashing. Because this film is thinner than the mean free path of air molecules, the interior airflow transfers momentum with an unusually high velocity comparable to the speed of sound and generates a stress 10 times stronger than the airflow in common situations. Such a large stress initiates Kelvin-Helmholtz instabilities at small length scales and effectively produces splashing. Our model agrees quantitatively with experimental verifications and brings a fundamental understanding to the ubiquitous phenomenon of drop splashing on smooth surfaces.T he common phenomenon of drop splashing on smooth surfaces may seem simple and natural to most people; however, its understanding is surprisingly lacking. Splashing is crucial in many important fields, such as the sprinkler irrigation and pesticide application in agriculture, ink-jet printing and plasma spraying in printing and coating industries, and spray cooling in various cooling systems; therefore its better understanding and effective control may make a far-reaching impact on our daily life. Starting in the 19th century, extensive studies on drop impact and splashing have covered a wide range of control parameters, including the impact velocity, drop size, surface tension, viscosity, and substrate properties (1-12), and various splashing criteria have been proposed and debated (13)(14)(15)(16)(17)(18). Nevertheless, at the most fundamental level the generation mechanism of splashing remains a big mystery.Recently a breakthrough has surprisingly revealed the importance of surrounding air and suggested the interaction between air and liquid as the origin of splashing (15,19,20). However, this interaction is highly complex: Below the drop air is trapped at both the impact center and the expanding front (21-34), and above it the atmosphere constantly interacts with its top surface. As a result, even the very basic question of which part of air plays the essential role is completely unknown. Moreover, the analysis from classical aerodynamics (18) indicates that the viscous effect from air totally dominates any pressure influence, whereas the experiment contradictorily revealed a strong pressure dependence (15). Even more puzzling, it was revealed that the speed of sound in air plays an important role in splashing generation (15), although the impact speed is typically 10-100 times slower! Therefore, an entirely new and nonclassical interaction, which can directly connect these two distinct timescales, is required to solve this puzzle. Due to the poor understanding of underlying interaction, the fundamental instability that produces splashing is unclear: The prevailing model of Rayleigh-Taylor (RT) instability (35) contradicts the pressure-dependent observat...