Experiments on the mechanism of action of caerulein at the level of the guinea-pig ileum and colon

Tacca, M. Del; Soldani, Giulio; Crema, A.

doi:10.1007/bf01965759

Cited by 29 publications

(3 citation statements)

References 24 publications

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“…tion. This is in accordance with the observation of Del Tacca et al (7). Similar to the in situ result (rabbit), sympathetic nerve endings do not appear to be involved in the action of caerulein.…”

Section: Nicotinesupporting

confidence: 93%

Effects of Caerulein on Intestinal Tract and Gallbladder

Nakamura¹,

Koyama²,

Kojima³

et al. 1973

Jpn.J.Pharmacol

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Abstract-Caerulein produces an acceleration of motility of rabbit ileum (in situ). The effect appears to be based on peripheral action. Sympathetic nerve endings appear not to be involved in the action. In the small intestine transit test (mouse) caerulein accelerated the transit when carbon powder was present. It is therefore considered that caerulein does not induce generalized muscle contraction but rather a coordinated propulsion in the intestinal tract. Caerulein in a larger dose discontinues flow of content out of the stomach probably due to pyloric spasm. Caerulein produced contraction of rabbit gallbladder (in situ) at doses lower than the threshold dose of ileum motility acceleration. In isolated ileum of guinea-pig, caerulein produced contraction at low doses. The action of caerulein appears to be mediated through the nerve: it appears to act on non-nicotinic receptor of the cholinergic nervous element and accelerate liberation of acetylcholine. It also appears to act, at least in part, on the atropine-resistant nervous element. In isolated guinea-pig gallbladder, as different from the in situ case, caerulein produced contraction at doses almost equal to the threshold of contraction in isolated guinea-pig ileum. The action of caerulein appears to be a direct action on the gallbladder smooth muscle. Caerulein had no effect on isolated was deferens and uterus. For this reason, the action of caerulein is considered to be of organ specificity.Caerulein is a decapeptide which was extracted from the skin of Australian Hyla caerulea by Anastasi, Erspamer and Endean in 1967 (1). Amino acid composition and sequence of caerulein are shown in the following structure.Chemical structures

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Section: Nicotinesupporting

confidence: 93%

Effects of Caerulein on Intestinal Tract and Gallbladder

Nakamura¹,

Koyama²,

Kojima³

et al. 1973

Jpn.J.Pharmacol

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“…Isolated guinea-pig colon with the sympathetic extrinsic nerves intact, similar to that described by Rand and Ridehalg,32 was used according to Del Tacca, et al 33 The terminal colon (length 2-3 cm) was removed from adult female guinea pigs weighing 250-300 g and suspended in an organ bath containing oxygenated Tyrode solution at 35°. Movements were recorded on a smoked drum by using a frontal isotonic lever with a magnification 1:10 and exerting a tension of 2.5 g. Sympathetic stimulation was performed by means of bipolar electrodes made from silver wire (2 mm apart) placed around the periarterial nerves of the colon.…”

Section: -Methoxy-2-(p-nitrophenyl)acetic Acidmentioning

confidence: 99%

Conformational effects on the activity of drugs. 4. Cyclic analogs of 1-(p-nitrophenyl)-2-isopropylaminoethanol. Synthesis and evaluation of the adrenergic .beta.-receptor blocking activity of 2-(p-nitrophenyl)-4-isopropylmorpholine

Balsamo¹,

Crotti²,

Macchia³

et al. 1973

J. Med. Chem.

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“…Grossman (1970) proposed a receptor mechanism for gastrointestinal hormones in which a specific receptor had two in teracting sites for gastrin, cholecystokinin and secretin. Several workers have proposed that the gastrointestinal hormones release acetylcholine from intrinsic neurones (Jacoby and Marshall 1969; Tacca et al 1970Lipshutz et al 1971Vizi et al 1972Vizi et al , 1973 …”

mentioning

confidence: 99%