Expert Panel report on a study of Splenda in male rats

Brusick, David; Borzelleca, Joseph F.; Gallo, Michael A.; Williams, Gary M.; Kille, John W.; Hayes, A. Wallace; Pi‐Sunyer, F. Xavier; Williams, Christine A.; Burks, Wesley

doi:10.1016/j.yrtph.2009.06.013

Cited by 33 publications

(21 citation statements)

References 34 publications

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“…In treated rat samples with synthetic colourants, C18, C22 and C30 were (for all colourants); C20 and C24 (for brown chocolate), C26 and cholesterol (for yellow 2G) may be bound with one or more of synthetic colourants secreted in feces. As reported in Tables 1, 2 and 3, cotton seeds oil composition was similar to that obtained by Farag et al (1990), also the effect of the present synthetic colourants on incriminate of lipid fractions in treated rat feces are confirmed with others (Gaunt et al, 1972;Phillips et al, 1980;Maha 1990;Abou-Donia et al, 2008;Brusick et al, 2009). Also, these results are paralleled with the results of Abdel-Rahim et al (1989) who found that, synthetic 43 colourants influenced as hypocholesterolemic and hypolipimic agents.…”

Section: Determination Of Fatty Acid Composition By (Gc-ms)supporting

confidence: 89%

Biochemical Changes in Fatty Acids, Hydrocarbons and Sterols as well as Total Lipids of Albino Rats Ingested some Synthetic Colourants and Flavourants as Food Additives

El-Beltagi

Abdel-Rahim

2017

Not Sci Biol

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The present study was carried out to investigate the effect of ingested synthetic food colourants or flavourants on total lipids content feces. The feces of rats ingested synthetic food colourants or flavourants has more lipids than that of control feces. In treated rat feces some fatty acids were disappeared (C 19 ) or appeared (C 14 ) while the other were increased (C 15 , C 20 , C 18:2 ) or decreased (C 6 ) when compared with the control feces. Most of unsaturated fatty acids (un SFA) might bind with the synthetic food colourants or flavourants and secreted in feces, but less consumed than saturated fatty acids (SFA) which, observed on hydrocarbon components, but sterols including cholesterol were more secreted by synthetic food additives treatments. Generally, the increase of total lipids and lipid fractions in feces such as unsaturated fatty acids (un SFA), total sterols (TS) especially cholesterol maybe due to their abilities to bind with food additives and form complex which secreted in feces.

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Section: Determination Of Fatty Acid Composition By (Gc-ms)supporting

confidence: 89%

Biochemical Changes in Fatty Acids, Hydrocarbons and Sterols as well as Total Lipids of Albino Rats Ingested some Synthetic Colourants and Flavourants as Food Additives

El-Beltagi

Abdel-Rahim

2017

Not Sci Biol

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“…8 For sucralose to be approved as a food additive, over 100 studies were included in the Sucralose Food Additive Petition (compiled by McNeil company) to demonstrate product safety. 9 This is consistent with the 1958 Food Additive Amendment 10 that holds the manufacturer responsible for demonstrating product safety using well-conducted research and producing reliable results. Critical safety studies are available in the published literature and are briefly summarized below.…”

Section: Introductionsupporting

confidence: 77%

Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice

Soffritti

Padovani

Tibaldi

et al. 2016

International Journal of Occupational and Environmental Health

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Background: Sucralose is an organochlorine artificial sweetener approximately 600 times sweeter than sucrose and used in over 4,500 products. Long-term carcinogenicity bioassays on rats and mice conducted on behalf of the manufacturer have failed to show the evidence of carcinogenic effects.Objective: The aim of this study was to evaluate the carcinogenic effect of sucralose in mice, using a sensitive experimental design.Methods: Five groups of male (total n = 457) and five groups female (total n = 396) Swiss mice were treated from 12 days of gestation through the lifespan with sucralose in their feed at concentrations of 0, 500, 2,000, 8,000, and 16,000 ppm. Results:We found a significant dose-related increased incidence of males bearing malignant tumors (p < 0.05) and a significant dose-related increased incidence (p < 0.01) of hematopoietic neoplasias in males, in particular at the dose levels of 2,000 ppm (p < 0.01) and 16,000 ppm (p < 0.01).Conclusions: These findings do not support previous data that sucralose is biologically inert. More studies are necessary to show the safety of sucralose, including new and more adequate carcinogenic bioassay on rats. Considering that millions of people are likely exposed, follow-up studies are urgent.

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“…Rats consuming sucralose were also shown by Schiffman and colleagues 26 to gain more weight, a finding that initiated intense debate. 27 In addition to weight gain, both saccharin and aspartame have been associated with impaired glucose homeostasis in mice, 24,28,29 and aspartame was also shown to induce hyperinsulinemia, 25 impaired insulin tolerance 24,28 and worsened atherosclerosis in genetically-susceptible (ApoE ¡/¡ ) mice. 30,31 In contrast, Flatt and colleagues described anti-hyperglycemic and antihyperinsulinemic effects for saccharin in genetically obese (ob/ob) mice, coupled with attenuation of weight gain.…”

Section: Introductionmentioning

confidence: 99%

Non-caloric artificial sweeteners and the microbiome: findings and challenges

et al. 2015

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These authors equally contributed to this work. N on-caloric artificial sweeteners (NAS) are common food supplements consumed by millions worldwide as means of combating weight gain and diabetes, by retaining sweet taste without increasing caloric intake. While they are considered safe, there is increasing controversy regarding their potential ability to promote metabolic derangements in some humans. We recently demonstrated that NAS consumption could induce glucose intolerance in mice and distinct human subsets, by functionally altering the gut microbiome. In this commentary, we discuss these findings in the context of previous and recent works demonstrating the effects of NAS on host health and the microbiome, and the challenges and open questions that need to be addressed in understanding the effects of NAS consumption on human health.

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Expert Panel report on a study of Splenda in male rats

Cited by 33 publications

References 34 publications

Biochemical Changes in Fatty Acids, Hydrocarbons and Sterols as well as Total Lipids of Albino Rats Ingested some Synthetic Colourants and Flavourants as Food Additives

Biochemical Changes in Fatty Acids, Hydrocarbons and Sterols as well as Total Lipids of Albino Rats Ingested some Synthetic Colourants and Flavourants as Food Additives

Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice

Non-caloric artificial sweeteners and the microbiome: findings and challenges

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