Experts’ preferences for sarcopenia outcomes: a discrete-choice experiment from a working group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) in collaboration with the European Union of Geriatric Medicine Society (EUGMS)

Beaudart, Charlotte; Bauer, Jürgen; Landi, Francesco; Bruyère, Olivier; Reginster, Jean‐Yves; Hiligsmann, Mickaël

doi:10.1007/s40520-021-01794-2

Cited by 8 publications

(11 citation statements)

References 13 publications

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“…This is also in accordance with latest data from experts in the field considering falls as most import outcome. 28 Thereby, agreement on detailed operational definition of clinical outcomes (e.g., falls‐related hospitalization, or overall self‐reported falls, overall fractures, or osteoporotic fractures) is key to enable meta‐analytical comparison of predictive validity of sarcopenia definitions in the future.…”

Section: Discussionmentioning

confidence: 99%

Predictive validity of current sarcopenia definitions (EWGSOP2, SDOC, and AWGS2) for clinical outcomes: A scoping review

Stuck

Basile

Freystätter

et al. 2022

J cachexia sarcopenia muscle

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Over the last 3 years new definitions of sarcopenia by the Sarcopenia Definition and Outcome Consortium (2020, SDOC), European Working Group on Sarcopenia in Older People (2019, EWGSOP2) and Asian Working Group on Sarcopenia (2019, AWGS2) have been proposed. The objective of this scoping review was to explore predictive validity of these current sarcopenia definitions for clinical outcomes. We followed the PRISMA checklist for scoping reviews. Based on a systematic search performed by two independent reviewers of databases (Pubmed and Embase) articles comparing predictive validity of two or more sarcopenia definitions on prospective clinical outcomes published since January 2019 (the year these definitions were introduced) were included. Data were extracted and results collated by clinical outcomes and by sarcopenia definitions, respectively. Of 4493 articles screened, 11 studies (mean age of participants 77.6 (SD 5.7) years and 50.0% female) comprising 82 validity tests were included. Overall, validity tests on the following categories of clinical outcomes were performed: fracture (n = 40, assessed in one study), mortality (n = 18), function (n = 11), institutionalization (n = 7), falls (n = 4), and hospitalization (n = 2). Thereby, EWGSOP2 was investigated in 15 validity tests (18.3%) on all categories of clinical outcomes, whereas SDOC was investigated in four validity tests (4.9%) in one study on fractures in men only, and none of the validity tests investigated predictive validity by the AWGS2. However, we were not able to pool the data using a meta‐analytic approach due to important methodological heterogeneity between the studies. We identified various definitions of clinical outcomes that were used to test predictive validity of sarcopenia definitions suggesting that an agreement on an operational definition of a clinical outcome is key to advance in the field of sarcopenia. Moreover, data on predictive validity using the sarcopenia definitions by the SDOC and AWGS2 are still scarce and lacking, respectively. In a next step, prospective studies including both women and men are needed to compare predictive validity of current sarcopenia definitions on defined key clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Predictive validity of current sarcopenia definitions (EWGSOP2, SDOC, and AWGS2) for clinical outcomes: A scoping review

Stuck

Basile

Freystätter

et al. 2022

J cachexia sarcopenia muscle

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“…Muscle strength and physical performance can be measured directly with different assessment tests [13] (▶ Fig. 1a, b).…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia, More Than Just Muscle Atrophy: Imaging Methods for the Assessment of Muscle Quantity and Quality

Nikodinovska¹,

Ivanoski²

2023

Rofo

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Background Sarcopenia, a progressive reduction of muscle mass and function, is associated with adverse outcomes in the elderly. Sarcopenia and muscle atrophy are not equal processes. Low muscle strength in association with muscle quantity/quality reduction is currently the optimal method for assessing sarcopenia. There is a practical need for indirect measurement of muscle strength using state-of-the-art imaging techniques. Methods The following provides a narrative, broad review of all current imaging techniques for evaluating muscles and identifying sarcopenia, including DEXA, CT, MRI, and high-resolution ultrasound, their main strengths, weaknesses, and possible solutions to problems regarding each technique. Results and Conclusion Well-recognized imaging methods for the assessment of muscle mass are explained, including evaluation with DEXA, CT, and MRI muscle quantity assessment, ultrasound evaluation of muscle thickness and CSA, and their correlations with established muscle mass calculation methods. A special focus is on imaging methods for muscle quality evaluation. Several innovative and promising techniques that are still in the research phase but show potential in the assessment of different properties of muscle quality, including MRI DIXON sequences, MRI spectroscopy, Diffusion Tensor Imaging, ultrasound echo intensity, ultrasound elastography, and speed-of-sound ultrasound imaging are briefly mentioned. Key Points: Citation Format

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“…Physical function is de ned as an objectively observable systemic body mobile function. It involves not only muscle function, but also nervous system function, which is a multidimensional concept [2]. Decreased physical function increases the risk of falls in older adults [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of early mental state changes on physical functions in elderly patients with a history of falls

Cui

Liu

Qin

et al. 2023

Preprint

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Background: Fear of falling is a potential consequence of falling in older adults. Whether such fall-related psychological concerns in turn affect physical function? Especially those who have a history of falling but have not been diagnosed with anxiety, depression or both. This study aimed to clarify the effects of early psychological changes on the physical function of order patients. Methods: The 111 participants with falling history were divided into the poor physical function (PPF) group with SPPB≤9 and the good physical function (GPF) group with SPPB>10. Their physical function was assessed through 4-meter gait speed (4MGS), five times sit-to-stand test (FTSST), grip strength, and Timed Up and Go tests TUGT. Their mental state was assessed by the self-rating anxiety/depression scale (SAS/SDS). Results: (1) SAS/SDS scores were negatively correlated with the SPPB score, gait speed, and maximum grip strength (males). (2) Multivariate logistic regression analysis showed that the SPPB score was subject to such independent influence factors: cerebrovascular disease (OR =15.615; P =0.001), normal ratio of grip strength (OR =0.046; P =0.008), TUGT (OR =1.671; P <0.001), and SDS score (OR =1.155; P =0.005). (3) The area under the ROC curve was 0.699 (0.601, 0.797) for SAS score, with a sensitivity of 0.776 and a specificity of 0.547; the AUC was 0.694 (0.596, 0.792) for SDS score, with a sensitivity of 0.586 and a specificity of 0.755. Conclusions: This study showed that the higher SAS/SDS scores corresponded to poorer physical performance. SAS/SDS scores were to some extent predictive of physical function among older adults with a history of falls.

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Cited by 8 publications

References 13 publications

Predictive validity of current sarcopenia definitions (EWGSOP2, SDOC, and AWGS2) for clinical outcomes: A scoping review

Predictive validity of current sarcopenia definitions (EWGSOP2, SDOC, and AWGS2) for clinical outcomes: A scoping review

Sarcopenia, More Than Just Muscle Atrophy: Imaging Methods for the Assessment of Muscle Quantity and Quality

Effects of early mental state changes on physical functions in elderly patients with a history of falls

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