Expiratory and inspiratory forced vital capacity and one‐second forced volume in asymptomatic never‐smokers in Norway

Gulsvik, Amund; Tosteson, Tor D.; Bakke, P.; Humerfelt, Sjur; Weiss, Scott T.; Speizer, Frank E.

doi:10.1046/j.1365-2281.2001.00377.x

Cited by 72 publications

(82 citation statements)

References 30 publications

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“…Although the number of subjects in the present data set are smaller than one might want, the results are consistent both with reference values reported from previous studies in the elderly [3,4] and values reported from studies in younger age groups [2,5,9,10]. This applies to both estimated age and height coefficients and measures of variation in the data, as shown in table 4.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers

Hardie¹,

Buist²,

Vollmer³

et al. 2002

Eur Respir J

425

294

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The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has defined stage 1 chronic obstructive pulmonary disease (COPD) as forced expiratory volume in one second/forced vital capacity (FEV1/FVC)% <70% and a FEV1% predicted of >80%. Stage 2 has been defined as FEV1/FVC <70% and a FEV1% pred of <80%. The authors examined the extent of COPD misdiagnosis using this definition in healthy, never-smoker, asymptomatic adults aged >70 yrs in Bergen, Norway. A respiratory questionnaire was mailed to a random sample of 2,871 persons aged>70 yrs. In a random, well-defined subgroup of 208 never-smoker respondents with no current respiratory disease and significant dyspnoea or heart disease/hypertension complicated with dyspnoea, 71 were able to perform an acceptable spirometry. Approximately 35% of these healthy, elderly never-smokers had an FEV1/FVC% of <70% and would be classified as having at least a stage 1 COPD. This percentage increased with age and in those aged >80 yrs ∼50% would be classified as having COPD and approximately one-third would have an FEV1of <80% pred (stage 2 COPD). The estimated 5th percentile of FEV1was consistently <80% pred.The Global Initiative for Chronic Obstructive Lung Disease criteria will probably lead to a significant degree of over-diagnosis of chronic obstructive pulmonary disease in those aged >70 yrs. The criteria used to define the various stages of chronic obstructive pulmonary disease need to be age-specific.

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Section: Discussionsupporting

confidence: 92%

“…The present study subjects came from a random sample of the general population. Another reason may have been that age-related decline of FEV1 accelerates in the elderly [4,9,10]. The present sample was started at age 70 yrs and thus, only looked at the steepest part of the age/FEV1 curve.…”

Section: Discussionmentioning

confidence: 99%

Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers

Hardie¹,

Buist²,

Vollmer³

et al. 2002

Eur Respir J

425

294

View full text Add to dashboard Cite

show abstract

“…Although never-smokers without wheeze or asthma were selected, in common with most studies that reported reference equations, asymptomatic disease could not be rules out. The increasing decline with age, observed in the current females (data not shown) and reported by others [17,18,20], may also be due to effects of poorer health.…”

Section: Discussionsupporting

confidence: 74%

Sources of variation in forced expiratory volume in one second and forced vital capacity

Chinn

Jarvis²,

Svanes³

et al. 2006

Eur Respir J

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Published prediction equations for lung function differ considerably, but the components of population variation responsible for the differences are unknown.Data were analysed for 6,323 never-smoking adults who did not report wheeze or asthma, from 42 centres participating in the European Community Respiratory Health Survey. Means and components of variance were estimated for males and females aged 20-24 yrs, and the relationships with age and height were examined in those aged 25-44 yrs.Mean lung function for those aged 20-24 yrs differed between centres, but variation could not be wholly attributed to differences in population or equipment. The maximum difference in means by equipment type was 101 mL for FVC in males. Equipment differences were not statistically significant adjusted for country, but differences in mean forced expiratory volume in one second and forced vital capacity by country, adjusted for instrument, were statistically significant in males. Differences between centres in relation to age and height had less influence on predicted values.In conclusion, there are unexplained differences in lung function between ethnically similar nonsmoking symptom-free populations. Neither national reference curves nor those based on the same ethnic group can be guaranteed to give accurate norms of lung health.

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“…Case subjects had COPD with a post-bronchodilator (BD) FEV 1 /FVC ratio , 0.7 and FEV 1 , 80% predicted. 7 Control subjects had normal spirometry (post-BD FEV 1 /FVC, Ն 0.7; FEV 1 , Ն 80% predicted).…”

Section: Study Populationsmentioning

confidence: 97%

α; 1 -Antitrypsin Protease Inhibitor MZ Heterozygosity Is Associated With Airflow Obstruction in Two Large Cohorts

Sørheim

Bakke

Gulsvik

et al. 2010

Chest

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Background: Severe a 1 -antitrypsin defi ciency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of a 1 -antitrypsin, but whether they have an increased risk of COPD is uncertain. Methods: We compared PI MZ and PI MM individuals in two large populations: a case-control study from Norway (n 5 1,669) and a multicenter family-based study from Europe and North America (n 5 2,707). We sought to determine whether PI MZ was associated with the specifi c COPD-related phenotypes of lung function and quantitative CT scan measurements of emphysema and airway disease. Results: PI MZ was associated with a 3.5% lower FEV 1 /FVC ratio in the case-control study ( P 5 .035) and 3.9% lower FEV 1 /vital capacity (VC) ratio in the family study ( P 5 .009). In the casecontrol study, PI MZ also was associated with 3.7% more emphysema on quantitative analysis of chest CT scans ( P 5 .003). The emphysema result was not replicated in the family study. PI MZ was not associated with airway wall thickness or COPD status in either population. Among subjects with low smoking exposure ( , 20 pack-years), PI MZ individuals had more severe emphysema on chest CT scan than PI MM individuals in both studies. Conclusions

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Expiratory and inspiratory forced vital capacity and one‐second forced volume in asymptomatic never‐smokers in Norway

Cited by 72 publications

References 30 publications

Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers

Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers

Sources of variation in forced expiratory volume in one second and forced vital capacity

α; 1 -Antitrypsin Protease Inhibitor MZ Heterozygosity Is Associated With Airflow Obstruction in Two Large Cohorts

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