Expiratory muscle fatigue impairs exercise performance

Vergès, Samuel; Sager, Y.; Erni, Corinne; Spengler, Christina M.

doi:10.1007/s00421-007-0491-y

Cited by 38 publications

(28 citation statements)

References 37 publications

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“…Prefatigue studies have shown either a significant decrease (69,79,132) or no change (24,113,118) in performance during subsequent heavy exercise. However, a problem with some of these studies is that respiratory muscle fatigue was not assessed (24,79,118) or was not quantified objectively using nerve stimulation techniques (69,132). Consequently, some of the studies may have failed to induce significant levels of respiratory muscle fatigue before subsequent exercise or overestimated the normally occurring level of fatigue in response to whole body exercise.…”

Section: Functional Consequences Of Respiratory Muscle Fatiguementioning

confidence: 99%

Exercise-induced respiratory muscle fatigue: implications for performance

Romer

Polkey²

2008

Journal of Applied Physiology

260

212

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Romer LM, Polkey MI. Exercise-induced respiratory muscle fatigue: implications for performance. J Appl Physiol 104: 879 -888, 2008. First published December 20, 2007 doi:10.1152/japplphysiol.01157.2007.-It is commonly held that the respiratory system has ample capacity relative to the demand for maximal O 2 and CO2 transport in healthy humans exercising near sea level. However, this situation may not apply during heavy-intensity, sustained exercise where exercise may encroach on the capacity of the respiratory system. Nerve stimulation techniques have provided objective evidence that the diaphragm and abdominal muscles are susceptible to fatigue with heavy, sustained exercise. The fatigue appears to be due to elevated levels of respiratory muscle work combined with an increased competition for blood flow with limb locomotor muscles. When respiratory muscles are prefatigued using voluntary respiratory maneuvers, time to exhaustion during subsequent exercise is decreased. Partially unloading the respiratory muscles during heavy exercise using low-density gas mixtures or mechanical ventilation can prevent exercise-induced diaphragm fatigue and increase exercise time to exhaustion. Collectively, these findings suggest that respiratory muscle fatigue may be involved in limiting exercise tolerance or that other factors, including alterations in the sensation of dyspnea or mechanical load, may be important. The major consequence of respiratory muscle fatigue is an increased sympathetic vasoconstrictor outflow to working skeletal muscle through a respiratory muscle metaboreflex, thereby reducing limb blood flow and increasing the severity of exerciseinduced locomotor muscle fatigue. An increase in limb locomotor muscle fatigue may play a pivotal role in determining exercise tolerance through a direct effect on muscle force output and a feedback effect on effort perception, causing reduced motor output to the working limb muscles. respiratory muscles; exercise; diaphragm; abdominals; magnetic stimulation; metaboreflex THE PURPOSE OF THIS MINIREVIEW is to address the question of whether the respiratory demands of exercise contribute significantly toward exercise limitation, either directly through limitations of the respiratory muscle pump or indirectly through effects on limb blood flow and locomotor muscle fatigue. We describe the mechanical and metabolic costs of meeting the ventilatory requirements of exercise. We then ask whether the respiratory muscles fatigue with exercise, what factors contribute to any such fatigue, and what the implications of these factors are for exercise tolerance. Finally, we deal with the potential mechanisms by which respiratory muscle fatigue could compromise exercise tolerance and whether it is possible to overcome this potential respiratory limitation. Our review focuses on the healthy young adult exercising near sea level. However, we also consider special circumstances that determine the balance between metabolic demand and respiratory system capacity in the highly trained endurance ...

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Section: Functional Consequences Of Respiratory Muscle Fatiguementioning

confidence: 99%

Exercise-induced respiratory muscle fatigue: implications for performance

Romer

Polkey²

2008

Journal of Applied Physiology

260

212

View full text Add to dashboard Cite

show abstract

“…One approach to address this issue is to compare the whole body exercise responses between a fresh state and a fatigued state, when a certain group of muscles has been prefatigued. This particular approach has been used to highlight the contribution of respiratory muscle fatigue to exercise intolerance in healthy subjects (18,39,43). In this investigation, we planned to quantify the impact of preinduced quadriceps fatigue on a subsequent cycling exercise in healthy subjects and patients with COPD.…”

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confidence: 99%

Impact of preinduced quadriceps fatigue on exercise response in chronic obstructive pulmonary disease and healthy subjects

Gagnon¹,

Saey²,

Vivodtzev³

et al. 2009

Journal of Applied Physiology

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Gagnon P, Saey D, Vivodtzev I, Laviolette L, Mainguy V, Milot J, Provencher S, Maltais F. Impact of preinduced quadriceps fatigue on exercise response in chronic obstructive pulmonary disease and healthy subjects. J Appl Physiol 107: 832-840, 2009. First published July 2, 2009 doi:10.1152/japplphysiol.91546.2008.-Exercise intolerance in chronic obstructive pulmonary disease (COPD) results from a complex interaction between central (ventilatory) and peripheral (limb muscles) components of exercise limitation. The purpose of this study was to evaluate the influence of quadriceps muscle fatigue on exercise tolerance and ventilatory response during constant-workrate cycling exercise testing (CWT) in patients with COPD and healthy subjects. Fifteen patients with COPD and nine age-matched healthy subjects performed, 7 days apart, two CWTs up to exhaustion at 80% of their predetermined maximal work capacity. In a randomized order, one test was performed with preinduced quadriceps fatigue and the other in a fresh state. Quadriceps fatigue was produced by electrostimulation-induced contractions and quantified by maximal voluntary contraction and potentiated twitch force (TwQ pot). Endurance time and ventilatory response during CWT were compared between fatigued and fresh state. Endurance time significantly decreased in the fatigued state compared with the fresh condition in COPD (356 Ϯ 69 s vs. 294 Ϯ 45 s, P Ͻ 0.05) and controls (450 Ϯ 74 s vs. 340 Ϯ 45 s, P Ͻ 0.05). Controls showed significantly higher ventilation and end-exercise dyspnea scores in the fatigued condition, whereas, in COPD, fatigue did not influence ventilation or dyspnea during exercise. The degree of ventilatory limitation, as expressed by the V E/ maximum voluntary ventilation ratio, was similar in both conditions in patients with COPD. We conclude that it is possible to induce quadriceps fatigue by local electrostimulation-induced contractions. Our findings demonstrate that peripheral muscle fatigue is an additional important factor, besides intense dyspnea, that limits exercise tolerance in COPD. quadriceps muscle fatigue; exercise tolerance; ventilatory response; electrostimulation EXERCISE INTOLERANCE IS ASSOCIATED with poor quality of life (16) and increased mortality (28)

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“…The measurements were repeated 10 times. The three highest measurement values with an error of 5% or less were selected and the mean of the three values was calculated 7) . As measures of respiratory response, minute ventilation (V were measured using an exhaled gas analyzer (AE-300S, Minato, Osaka, Japan) on a breath-by-breath basis.…”

Section: Methodsmentioning

confidence: 99%